Transcriptomic and pathological profiling of a new congenic mouse model with Lepr mutation:Evaluating susceptibility to the development of obesity and NAFLD  

作　　者：MJ Mahesh Kumar Shailendra Arindkar Masum Saini Perumal Nagarajan 

机构地区：[1]National Institute of Immunology,New Delhi 100067,India [2]Center for Cellular and Molecular Biology,Hyderabad 500007,India [3]Regional Center for Biotechnology,Faridabad 121001,India

出　　处：《Genes & Diseases》2024年第3期34-38,共5页基因与疾病（英文）

摘　　要：Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and T2DM.For instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关 键 词：OBESITY NAFLD LEP 

分 类 号：R589.2[医药卫生—内分泌]