Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosis  

作　　者：Shuyu Li Zichen Xu Yi Wang Lizhao Chen Xiangxiu Wang Yanghao Zhou Daoxi Lei Guangchao Zang Guixue Wang 

机构地区：[1]Key Laboratory of Biorheological Science and Technology of Ministry of Education,National and Local Joint Engineering Laboratory for Vascular Implants,Bioengineering College of Chongqing University,Chongqing 400030,China [2]College of Basic Medical Sciences,Chongqing Medical University,Chongqing 400016,China [3]Department of Neurosurgery,Daping Hospital,Army Medical Center of PLA,Army Medical University,Chongqing 400042,China

出　　处：《Genes & Diseases》2024年第3期206-219,共14页基因与疾病（英文）

基　　金：supported in part by the National Natural Science Foundation of China(No.31971242,12032007);the Chongqing Science and Technology Bureau(China)(No.cstc2021jsyj-yzysbA0057);the Joint Medical Research Project of Chongqing Science and Technology Bureau and Chongqing Health Commission(China)(No.2018ZDXM032).

摘　　要：Atherosclerotic cardiovascular disease and its complications are a high-incidence disease worldwide.Numerous studies have shown that blood flow shear has a huge impact on the function of vascular endothelial cells,and it plays an important role in gene regulation of pro-inflammatory,pro-thrombotic,pro-oxidative stress,and cell permeability.Many impor-tant endothelial cell mechanosensitive genes have been discovered,including KLK10,CCN gene family,NRP2,YAP,TAZ,HIF-1α,NF-kB,FOS,JUN,TFEB,KLF2/KLF4,NRF2,and ID1.Some of them have been intensively studied,whereas the relevant regulatory mechanism of other genes remains unclear.Focusing on these mechanosensitive genes will provide new strategies for therapeutic intervention in atherosclerotic vascular disease.Thus,this article reviews the mechanosensitive genes affecting vascular endothelial cells,including classical pathways and some newly screened genes,and summarizes the latest research progress on their roles in the pathogenesis of atherosclerosis to reveal effective therapeutic targets of drugs and provide new insights foranti-atherosclerosis.

关 键 词：ATHEROSCLEROSIS Blood flow Endothelial cell Mechanosensitive gene Therapeutic target 

分 类 号：R543.5[医药卫生—心血管疾病]