Microbiome and intestinal pathophysiology in post-acute sequelae of COVID-19  

作　　者：Jilei Zhang Yongguo Zhang Yinglin Xia Jun Sun 

机构地区：[1]Division of Gastroenterology and Hepatology,Department of Medicine,University of Ilinois Chicago,IL60612,USA [2]Uic Cancer Center,Department of Microbiology and Immunology,University of Ilinois Chicago,Chicago,IL60612,USA [3]Jesse Brown VA Medical Center,Chicago,IL60612,USA

出　　处：《Genes & Diseases》2024年第3期220-231,共12页基因与疾病（英文）

基　　金：supported by the IlINET RECOVER pilot grant(to J.S.and Y.X.);Crohn's&Colitis Foundation Senior Research Award(No.902766 to J.S.);United States Department of Defense Congressionally Directed Medical Research Programs(No.BC191198 to J.S.);VA Merit Award BX-19-00 to J.S.

摘　　要：Long CoVID,also known for post-acute sequelae of CovID-19,describes the people who have the signs and symptoms that continue or develop after the acute coviD-19 phase.Long CovID patients suffer from an inflammation or host responses towards the virus approx-imately 4 weeks after initial infection with the SARS CoV-2 virus and continue for an unchar-acterized duration.Anyone infected with CovID-19 before could experience long-CcovID conditions,including the patients who were infected with SARS CoV-2 virus confirmed by tests and those who never knew they had an infection early.People with long CoviD may experience health problems from different types and combinations of symptoms over time,such as fa-tigue,dyspnea,cognitive impairments,and gastrointestinal(Gl)symptoms(e.g.,nausea,vom-iting,diarrhea,decreased or loss of appetite,abdominal pain,and dysgeusia).The critical role of the microbiome in these Gl symptoms and long CovID were reported in clinical patients and experimental models.Here,we provide an overall view of the critical role of the Gl tract and microbiome in the development of long COVID,including the clinical Gl symptoms in patients,dysbiosis,viral-microbiome interactions,barrier function,and inflammatory bowel disease patients with long CovID.We highlight the potential mechanisms and possible treatment based on Gl health and microbiome.Finally,we discuss challenges and future direction in the long CoVID clinic and research.

关 键 词：Gastrointestinal symptoms Gl tract Gut microbiome Inflammatorybowel diseases Intestinal barrier Long CoVID Metabolites Tight junctions 

分 类 号：R574[医药卫生—消化系统] R563.1[医药卫生—内科学]