Osteoarthritis versus psoriasis arthritis: Physiopathology, cellular signaling, and therapeutic strategies  

作　　者：Salma Nassor Juma Junguang Liao Yuping Huang Rexhina Vlashi Qingwan Wang Bocong Wu Dan Wang Mengrui Wu Guiqian Chen 

机构地区：[1]College of Life Science and Medicine,Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine,Zhejiang Sci-Tech University,Hangzhou,Zhejiang 310018,China [2]Department of Cell and Developmental Biology,College of Life Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,China

出　　处：《Genes & Diseases》2024年第3期232-247,共16页基因与疾病（英文）

摘　　要：Osteoarthritis and psoriasis arthritis are two degenerative forms of arthritis that share similar yet also different manifestations at the histological,cellular,and clinical levels.Rheumatologists have marked them as two entirely distinct arthropathies.Given recent dis-coveries in disease initiation and progression,potential mechanisms,cellular signaling path-ways,and ongoing clinical therapeutics,there are now more opportunities for discovering osteoarthritis drugs.This review summarized the osteoarthritis and psoriasis arthritis signaling pathways,crosstalk between BMP,WNT,TGF-β,VEGF,TLR,and FGF signaling pathways,bio-markers,and anatomical pathologies.Through bench research,we demonstrated that regen-erative medicine is a promising alternative for treating osteoarthritis by highlighting significant scientific discoveries on entheses,multiple signaling blockers,and novel molecules such as immunoglobulin new antigen receptors targeted for potential drug evaluation.Furthermore,we offered valuable therapeutic approaches with a multidisciplinary strategy to treat patients with osteoarthritis or psoriasis arthritis in the coming future in the clinic.

关 键 词：Newantigen receptor OSTEOARTHRITIS PHYSIOPATHOLOGY Psoriasisarthritis Signaling pathway 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R68[医药卫生—临床医学]