Fibroblast growth factor 21: An emerging pleiotropic regulator of lipid metabolism and the metabolic network  

作　　者：Shuo Li Tiande Zou Jun Chen Jiaming Li Jinming You 

机构地区：[1]Jiangxi Province Key Laboratory of Animal Nutrition,Jiangxi Agricultural University,Nanchang,Jiangxi 330045,China

出　　处：《Genes & Diseases》2024年第3期248-263,共16页基因与疾病（英文）

基　　金：supported by the Jiangxi Provincial Cultivation Program for Academic and Technical Leaders of Major Subjects(China)(No.20212BCJ23009);the National Natural Science Foundation of China(No.32002191);the Jiangxi Pig Industry Technology System(China)(JXARS-03-Nutrition and Feed).

摘　　要：Fibroblast growth factor 21(FGF21)was originally identified as an important meta-bolic regulator which plays a crucial physiological role in regulating a variety of metabolic pa-rameters through the metabolic network.As a novel multifunctional endocrine growth factor,the role of FGF21 in the metabolic network warrants extensive exploration.This insight was obtained from the observation that the FGF21-dependent mechanism that regulates lipid metabolism,glycogen transformation,and biological effectiveness occurs through the coordi-nated participation of the liver,adipose tissue,central nervous system,and sympathetic nerves.This review focuses on the role of FGF21-uncoupling protein 1(UCP1)signaling in lipid metabolism and how FGF21 alleviates non-alcoholic fatty liver disease(NAFLD).Additionally,this review reveals the mechanism by which FGF21 governs glucolipid metabolism.Recent research on the role of FGF21 in the metabolic network has mostly focused on the crucial pathway of glucolipid metabolism.FGF21 has been shown to have multiple regulatory roles in the metabolic network.Since an adequate understanding of the concrete regulatory path-ways of FGF21 in the metabolic network has not been attained,this review sheds new light on the metabolic mechanisms of FGF21,explores how FGF21 engages different tissues and organs,and lays a theoretical foundation for future in-depth research on FGF21-targeted treatment of metabolic diseases.

关 键 词：ADIPOSE FGF21 Insulin homeostasis Lipid metabolism Liver Metabolicnetwork 

分 类 号：R589[医药卫生—内分泌] R329.2[医药卫生—内科学]