Tumor microenvironment of cancer stem cells:Perspectives on cancer stem cell targeting  

作　　者：Qianqian Guo Yi Zhou Tianyuan Xie Yin Yuan Huilong Li Wanjin Shi Lufeng Zheng Xiaoman Li Wenzhou Zhang 

机构地区：[1]Department of Pharmacy,The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital,Zhengzhou,Henan 450003,China [2]Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210023,China [3]School of Life Science and Technology,Jiangsu Key Laboratory of Carcinogenesis and Intervention,China Pharmaceutical University,Nanjing,Jiangsu 211198,China

出　　处：《Genes & Diseases》2024年第3期275-302,共28页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82173842,82204432);the Medical Science and Technology Research Project of Henan Province,China(No.SBGJ202003010);the Henan Province Science and Technology Research Project(No.222102310414);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions(China).

摘　　要：There are few tumor cell subpopulations with stem cell characteristics in tumor tis-sue,defined as cancer stem cells(CSCs)or cancer stem-like cells(CSLCs),which can recon-struct neoplasms with malignant biological behaviors such as invasiveness via self-renewal and unlimited generation.The microenvironment that CsCs depend on consists of various cellular components and corresponding medium components.Among these factors existing at a variety of levels and forms,cytokine networks and numerous signal pathways play an important role in signaling transduction.These factors promote or maintain cancer cell stem-ness,and participate in cancer recurrence,metastasis,and resistance.This review aims to summarize the recent molecular data concerning the multilayered relationship between CsCs and CsC-favorable microenvironments.We also discuss the therapeutic implications of target-ing this synergistic interplay,hoping to give an insight into targeting cancer cell stemness for tumortherapyandprognosis.

关 键 词：Cancer stem cells Cancerstem-like cells Cellular factors Non-cellularfactors Tumor microenvironment 

分 类 号：R73[医药卫生—肿瘤]