BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response  

作　　者：Zhenhai Li Wenchao Xu Feng Chen Jun Zhang Wei-Guo Zhu 

机构地区：[1]Guangdong Key Laboratory of Genome Instability and Human Disease Prevention,Department of Biochemistry and Molecular Biology,Shenzhen University School of Medicine,Shenzhen,Guangdong 518055,China [2]School of Pharmaceutical Sciences,Shenzhen University Health Science Center,Shenzhen,Guangdong 518055,China [3]Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center,International Cancer Center,Shenzhen University Health Science Center,Shenzhen,Guangdong 518055,China [4]Shenzhen Bay Laboratory,Shenzhen University School of Medicine,Shenzhen,Guangdong 518055,China [5]Marshall Laboratory of Biomedical Engineering,Shenzhen University School of Medicine,Shenzhen,Guangdong 518055,China

出　　处：《Genes & Diseases》2024年第1期19-22,共4页基因与疾病（英文）

基　　金：supported by the National Key R&D Program of China(No.2017YFA0503900);the National Natural Science Foundation of China(No.32090033,81720108027,81530074,82103275,82002986);the Science and Technology Program of Guangdong Province in China(No.2017B030301016);China Postdoctoral Science Foundation(No.2019M663092);Basic and Applied Basic Research Foundation of Guangdong Province(No.2019A1515110039,2019A1515110041,2021A1515011126);Shenzhen Municipal Commission of Science and Technology Innovation(China)(No.JCYJ20170818092450901,JCYJ20200109114214463).

摘　　要：Etoposide is widely used for cancer chemotherapy in the clinic.However,long-term etoposide treatment can lead to adverse effects or drug resistance.To improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer development.Firstly,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.

关 键 词：ETOPOSIDE DAMAGE cancer 

分 类 号：R73[医药卫生—肿瘤]