The single-cell landscape reveals unique tumor subsets and microenvironments associated with poor clinical outcomes in primary testicular diffuse large B-cell lymphoma  

作　　者：Zhouliang Bian Benhong Gu Guohai Shi Jiahui Guo Dong Li Hanlin Zengg Bin Jiang Daliu Min Hengchuan Su Yanjie Zhang 

机构地区：[1]Department of Oncology,Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201900,China [2]Shanghai Institute of Precision Medicine,Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200125,China [3]Department of Urology,Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200336,China [4]Department of Urology,Fudan University Shanghai Cancer Center,Shanghai200032,China [5]Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China [6]Department of Oncology,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai 200233,China

出　　处：《Genes & Diseases》2024年第1期80-83,共4页基因与疾病（英文）

基　　金：supported by grants from the National Natural Science Foundation of China,China(No.82072638 to Y.Z.and No.81602222 to H.S.);the Biobank Program of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China(No.YBKB202217 to Y.Z.).

摘　　要：Diffuse large B cell lymphoma(DLBCL)is one of the most prevalent lymphoid malignancies.The current standard of care can cure about two-thirds of DLBCL patients.1 Primary testicular diffuse large B-cell lymphoma(PT-DLBCL)is a rare but highly aggressive form of mature B-cell lymphoma that accounts for approximately 1%-9%of testicular malignancies.Different from nodal DLBCL,PT-DLBCL has a markedly worse prognosis because of inferior response to the current treatment regimens and significant extranodal tropism.2 Three main questions remained unresolved in the field of PT-DLBCL research.

关 键 词：LYMPHOMA markedly prognosis 

分 类 号：R733[医药卫生—肿瘤]