RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations  

作　　者：Hongxia Zhang Yueya Zhong Yuanming He Yujia Xu Ying Ren Haixia Zhuang Tong Sun Zhigang Zhu Xinliang Mao 

机构地区：[1]Institute of Clinical Pharmacology,Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510403,China [2]Guangdong Provincial Key Laboratory of Protein Modification and Degradation,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou,Guangdong 511436,China [3]Department of Pharmacology,College of Pharmaceutical Sciences,Soochow University,Suzhou,Jiangsu 215123,China [4]Division of Hematology&Oncology,Department of Geriatrics,Guangzhou First People's Hospital,College of Medicine,South China University of Technology,Guangzhou,Guangdong 510180,China

出　　处：《Genes & Diseases》2024年第1期87-90,共4页基因与疾病（英文）

基　　金：supported by The National Natural Science Foundation of China(No.81770154,81970194,and 82170176);the National Key Research and Development Program of China(No.2022YFC2705003);Guangzhou Medical University Discipline Construction Funds(Basic Medicine)(China)(No.JCXKJS2022A05);Guangzhou Key Discipline of Medicine(Geriatric Medicine)(China)(No.ZDXK202103).

摘　　要：Chronic myelogenous leukemia(CML)is a malignancy from bone marrow myeloid stem cells mainly driven by the fusion gene BCR-ABL.In addition to BCR-ABL,other genes including RNF6 are also dysregulated in CML cells.1 RNF6,a ubiquitin ligase of the RING family,promotes various cancer cell proliferation,chemoresistance,and tumor growth in vivo by targeting various proteins for ubiquitination and degradation,including SHP1,TLE3,FOXA1,and MAD1.^(2) However,its specific mechanism in CML is not known.

关 键 词：UBIQUITIN MYELOGENOUS LEUKEMIA 

分 类 号：R733.7[医药卫生—肿瘤]