Self-shrinking supramolecular nanoparticles syndicate energy suppression and NIR-II mild photothermal amplification of mitochondrial oxidative stress for breast cancer therapy  

作　　者：Hongmei Liu Jiming Xu Mengjie Ye Hengbo Zhang Linlin Han Jingting Wang Peng Xue Yuejun Kang Zhigang Xu 

机构地区：[1]Key Laboratory of Luminescence Analysis and Molecular Sensing,Ministry of Education,School of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices,Southwest University,Chongqing 400715,China [2]Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158,China [3]Yibin Academy of Southwest University,Yibin 644000,China

出　　处：《Nano Research》2024年第5期4314-4328,共15页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22375168);Chongqing Talents of Exceptional Young Talents Project,China(Nos.CQYC202005029,cstc2021ycjh-bgzxm0061);Shuangcheng cooperative agreement research grant of Yibin,China(No.XNDX2022020013);the Innovation Platform for Academicians of Hainan Province.

摘　　要：Photothermal therapy(PTT)may lead to healthy tissue damage,tumor metastasis,and recurrence,which makes mild photothermal therapy(mild PTT)stand out.However,overcoming heat resistance,insufficient therapeutic effect,and poor photothermal conversion efficiency has become new challenge.Herein,we report a dynamic supramolecular nanocarrier formed from amide-sericin and aldehyde-polyhydroxy glucan(denoted as SDA),the loose cavity of which can be filled by using the pharmaceutical combination of lonidamine(LND)and NIR-II photothermal agent of IR-1061,producing SDLI with a tighter inner hole,smaller and uniform particle size and excellent stability due to multiple pulling forces.Moreover,the intricate internal network structure prevents the hydrophobic IR-1061 from forming aggregates in the small cavity,and the photothermal conversion efficiency(PCE)can reach 48.9%.At the acidic tumor microenvironment of pH 6.5,the controlled release of LND can solve the problem of heat resistance of NIR-II mild PTT and significantly improve the therapeutic effect of NIR-II mild PTT.Meanwhile,SDLI also shows a reasonable tumor inhibition rate,so the synergistic strategy of inhibiting tumor energy metabolism and NIR-II mild PTT to magnify mitochondrial oxidative stress,continuous cell stress state-induced immunogenic cell death to promote the induction of tumor apoptosis is proposed to achieve more effective cancer treatment.

关 键 词：self-shrinkage dynamic supramolecular nanoparticles tumor energy metabolism NIR-II mild photothermal therapy mitochondrial oxidative stress 

分 类 号：R737.9[医药卫生—肿瘤]