组蛋白乙酰化在放疗相关DNA损伤中的研究进展  

Research progress in histone acetylation in radiation-related DNA damage

作　　者：冯静怡 姚何莹 朱海涛[1] 姜伟 廖翔 Feng Jingyi;Yao Heying;Zhu Haitao;Jiang Wei;Liao Xiang(Department of Radiology,Affiliated Hospital of Jiangsu University,Zhenjiang 210031,China)

机构地区：[1]江苏大学附属医院放射科,镇江210031

出　　处：《中华放射肿瘤学杂志》2024年第4期378-382,共5页Chinese Journal of Radiation Oncology

摘　　要：放疗通过诱导DNA损伤的方式杀伤肿瘤细胞,是多种恶性肿瘤的一线治疗手段。然而,肿瘤细胞对放疗有不同的敏感性,最终导致不同的治疗效果。由组蛋白乙酰转移酶(HAT)和组蛋白去乙酰化酶(HDAC)调控的组蛋白乙酰化通过影响DNA损伤修复参与细胞放疗敏感性的调节,主要机制有募集DNA修复相关蛋白、介导染色质的动态变化。本文就组蛋白乙酰化修饰在肿瘤放疗中的作用做一综述,为基于组蛋白乙酰化的放疗增敏策略提供依据。Radiotherapy is a first-line treatment for a variety of malignant tumors by inducing DNA damage to kill tumor cells.However,tumor cells have different sensitivities to radiotherapy,ultimately leading to different therapeutic effects.Histone acetylation,regulated by histone acetyltransferase(HAT)and histone deacetylase(HDAC),is involved in the regulation of cell radiation sensitivity by influencing DNA damage repair.The main mechanisms are recruiting DNA repair related proteins and mediating chromatin dynamic changes.In this article,the role of histone acetylation modification in tumor radiotherapy was reviewed,aming to provide the basis for the radiotherapy sensitization strategy based on histone acetylation.

关 键 词：放射疗法 组蛋白类 表观遗传修饰 乙酰化作用 DNA损伤 

分 类 号：R730.55[医药卫生—肿瘤]