妊娠合并宫颈大细胞神经内分泌癌和低钠血症一例  

Large Cell Neuroendocrine Carcinoma of the Uterine Cervix in Pregnancy Combined with Hyponatremia:A Case Report

作　　者：王芳 贾泽南 郑婧[1] 王惠玲[1] 朱宝玉 吴珍珍[1] 刘青[1] WANG Fang;JIA Ze-nan;ZHENG Jing;WANG Hui-ling;ZHU Bao-yu;WU Zhen-zhen;LIU Qing(Department of Gynecology,Gansu Provincial Maternity and Child Care Hospital(Gansu Province Central Hospital),Lanzhou 730050,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)妇科,兰州730050

出　　处：《国际妇产科学杂志》2024年第2期198-202,共5页Journal of International Obstetrics and Gynecology

基　　金：甘肃省卫生健康行业科研计划项目(GSWSKY2020-36)。

摘　　要：回顾分析1例妊娠合并宫颈大细胞神经内分泌癌ⅢC1(r)期剖宫产术后行静脉化疗发生低钠血症的患者,经放化疗治疗原发肿瘤,对症治疗纠正低钠血症达完全缓解后6个月,出现疾病复发,通过化疗联合靶向及免疫治疗,患者因出现分布性休克、电解质紊乱,患者家属放弃治疗,随访至2023年5月,患者死亡。宫颈大细胞神经内分泌癌是一种恶性程度高、预后差的恶性肿瘤,患者出现低钠血症可能与肿瘤的不良预后相关,临床上容易被化疗的不良反应所掩盖。临床医生应掌握低钠血症的临床表现,提高早期识别的能力,做到早诊断、早治疗,积极改善患者预后。Retrospective analysis of a case of pregnancy complicated with cervical large cell neuroendocrine carcinoma stageⅢC1(r)cesarean section after intravenous chemotherapy occurred hyponatremia.Chemotherapy and radiation were employed to treat the main tumor,and symptomatic treatment was utilized to deal with hyponatremia.After 6 months of complete remission,there was a recurrence of the disease.Through the chemotherapy combined with targeted and immunotherapy,the patient experienced distributed shock and electrolyte disorder,and the patient′s family to give up the treatment.The follow-up didn′t break off until the patient died in May 2023.The prognosis for cervical large cell neuroendocrine carcinoma is poor due to its high level of aggressiveness.Hyponatremia may be associated with a poor prognosis of the tumor,which in clinical practice is easily obscured by severe effects to chemotherapy in the clinic.Understanding the clinical signs of hyponatremia,improve the ability of early recognition,obtaining an early diagnosis and course of therapy,and actively enhancing patient prognosis are all important for clinicians.

关 键 词：宫颈肿瘤 癌 神经内分泌 低钠血症 ADH分泌不当综合征 预后 

分 类 号：R737.33[医药卫生—肿瘤] R714.2[医药卫生—临床医学]