苯并[a]芘对生殖系统的毒性作用及其机制研究进展  

Research Progress on Toxic Effects of Benzo(a)pyrene on Reproductive System and Its Mechanism

作　　者：王惠增 刘秉春[2] 陈红 徐沛欣 郭鑫 袁建龙[1] Wang Huizeng;Liu Bingchun;Chen Hong;Xu Peixin;Guo Xin;Yuan Jianlong(Department of Laboratory Medicine,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Stem Cell Research Center,The Affiliated Hospital of Inner Mongolia Medical University/Inner Mongolia Autonomous Region Tumor Cell Gene Detection Application and Research Engineering Laboratory,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院检验科,呼和浩特010050 [2]内蒙古医科大学附属医院干细胞实验室/内蒙古自治区肿瘤细胞基因检测应用与研究工程实验室,呼和浩特010050

出　　处：《生态毒理学报》2024年第2期165-183,共19页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金项目(31960154);中央引导地方科技发展资金项目(2023ZY0004);内蒙古自治区“草原英才”工程青年创新创业人才项目(Q2022085);内蒙古自治区高等学校科学研究项目(NJZZ23017);内蒙古自治区自然科学基金项目(2023QN03047);内蒙古医科大学面上项目(YKD2022MS033)。

摘　　要：苯并[a]芘(benzo(a)pyrene,BaP)作为多环芳烃(polycyclic aromatic hydrocarbons,PAHs)的成员,是最早发现也是最具有代表性的环境污染物,通过空气、食物、水源等途径进入人体,引起细胞氧化应激损伤、DNA损伤和基因异常表达导致细胞死亡。研究表明雄性与雌性动物经BaP染毒后,其生殖器官、生殖细胞甚至激素水平均会受到影响,进而影响受精卵形成和胚胎发育,造成不良妊娠结局。因此,近年来BaP的生殖毒性受到广泛关注,其作用机制包括改变胞内活性氧水平、诱导细胞DNA损伤以及调控生殖发育相关基因、类固醇合成相关基因和促凋亡基因影响生殖发育。BaP作为环境毒物,不仅可以影响生态环境的稳定性,还可以影响生物的生殖发育,损害生态环境中的物种多样性,从长远来看,BaP的不良影响不但会威胁到陆地与海洋生物种群的稳定,还会破坏陆地和海洋生态系统的功能。本文将从生殖健康、配子与合子形成以及胚胎发育的角度,详细阐述BaP染毒对生殖系统的毒性作用与机制,为预防BaP引起的生殖危害、减少不良妊娠结局提供理论依据,旨在为BaP的环境毒性行为和对生物的毒性研究提供有效借鉴,为合理预防和缓解因接触BaP等环境毒物而带来的健康影响提供参考。Benzo(a)pyrene(BaP),as a member of the polycyclic aromatic hydrocarbons(PAHs),is the earliest discovered and most representative environmental pollutant.It enters the human body through the air,food,and water,causing cellular oxidative stress damage,DNA damage,and abnormal gene expression,leading to cell death.Studies have shown that when male and female animals are exposed to BaP,their reproductive organs,cells,and hormone levels are affected,which in turn will affect the formation of fertilized eggs and embryonic development,resulting in adverse pregnancy outcomes.Hence,the reproductive toxicity of BaP has received more attention in recent years.Its mechanism of action on reproductive development includes alteration of intracellular reactive oxygen s pecies levels,induction of cellular DNA damage,and modulation of genetic changes related to reproductive d evelopment,steroid synthesis and pro-apoptosis.BaP,as an environmental toxicant,could influence the stability of the ecological environment,the reproductive development of organisms and destroy the diversity of species in the ecosystems.In this review,we will detailly elaborate on the toxic effects and mechanisms of BaP on the reproductive system,and provide a theoretical evidence for prevention reproductive harm caused by BaP and the reduction of adverse pregnancy outcomes,with the aim to providing an effective reference for the study of BaP’s toxicity to the environment and organisms,and for the rational prevention and mitigation of the health effects of exposure to BaP or other environmental toxins.

关 键 词：苯并[a]芘(BaP) 生殖细胞 生殖毒性 生殖器官 激素 细胞毒性 

分 类 号：X171.5[环境科学与工程—环境科学]