DGKZ rs7951870多态性与中国汉族人群精神分裂症的关联性  

Association analysis of DGKZ rs7951870 polymorphism with schizophrenia in Chinese Han population

作　　者：王新 高慧婕[2] 刘超[2] WANG Xing;GAO Huijie;LIU Chao(School of Pharmacy,Binzhou Medical University,Yantai 264003,China;College of Pharmacy,Jining Medical University,Rizhao 276826,China)

机构地区：[1]滨州医学院药学院,烟台264003 [2]济宁医学院药学院,日照276826

出　　处：《济宁医学院学报》2024年第2期95-97,共3页Journal of Jining Medical University

基　　金：山东省自然科学基金(ZR2021MH164);贺林院士新医学临床转化工作站科研基金项目(JYHL2021MS08)。

摘　　要：目的 分析二酰基甘油激酶Zeta(Diacylglycerol kinase Zeta,DGKZ)基因多态性(single nucleotide polymorphism,SNP)与精神分裂症(SCZ)遗传易感性的相关性。方法 选取2018年2月至2019年5月于日照市第三人民医院住院治疗的211例SCZ患者(SCZ组),同期选择于本院239例健康体检者(对照组),采集外周静脉血,提取全基因组DNA,使用Taqman-MGB探针技术检测DGKZ基因rs7951870位点多态性,对比分析两组人群等位基因分布和基因频率的差异。结果 两组DGKZ rs7951870的等位基因分布和基因型频率没有显著性差异(DGKZ rs7951870:基因型χ^(2)=2.67,P=0.26;等位基因χ^(2)=1.07,P=0.30)。在加性模型(χ^(2)=0.84,P=0.36)、显性模型(χ^(2)=1.47,P=0.23)和隐性模型(χ^(2)=0.89,P=0.35)分析基础上rs7951870均不是SCZ的危险因素。结论 DGKZ rs7951870对中国汉族人群精神分裂症风险的影响非常小,后续仍然需要用更大样本数量的实验来验证这一发现。Objective This study aimed to explore the association between the single nucleotide polymorphisms(SNPs) of DGKZ and susceptibility to schizophrenia in Chinese Han population.Methods Collect peripheral venous blood and extract whole genome DNA.DNA from 239 healthy controls and 211 schizophrenic patients was genotyped for SNPs rs7951870 in DGKZ using a predesigned TaqMan SNP genotyping assay.From February 2018 to May 2019.Results No significant differences in allelic or genotypic frequencies of DGKZ rs7951870 were detected between cases and controls(DGKZ rs7951870:χ^(2)=2.67,P=0.26 by genotype,χ^(2)=1.07,P=0.30).On the basis of additive,dominant and recessive model analysis,rs7951870 is not a risk factor for SCZ(P>0.05).Conclusion Our results suggest that DGKZ rs7951870 SNPs are unlikely to play a major role in the pathogenesis of schizophrenia in Shandong Han population.However,these results should be validated by replication in larger and independent samples.

关 键 词：精神分裂症 二酰基甘油激酶Zeta 单核苷酸多态性 rs7951870 

分 类 号：R749.3[医药卫生—神经病学与精神病学]