Metal nanoparticles for cancer therapy:Precision targeting of DNA damage  

作　　者：Qian Chen Chunyan Fang Fan Xia Qiyue Wang Fangyuan Li Daishun Ling 

机构地区：[1]Institute of Pharmaceutics,Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [2]Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China [3]World Laureates Association(WLA)Laboratories,Shanghai 201203,China [4]Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province,Hangzhou 310009,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第3期1132-1149,共18页药学学报（英文版）

基　　金：funded by National Key Research and Development Program of China(2022YFB3203804,2022YFB3203801,2022YFB3203800);the Leading Talent of“Ten Thousand Plan”National High-Level Talents Special Support Plan,National Natural Science Foundation of China(32071374,32000985);Program of Shanghai Academic Research Leader under the Science and Technology Innovation Action Plan(21XD1422100,China);Program of Shanghai Science and Technology Development(22TS1400700,China);Zhejiang Provincial Natural Science Foundation of China(LR22C100001,LQ21H300003,China);Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20210900,China);CAS Interdisciplinary Innovation Team(JCTD-2020-08,China)。

摘　　要：Cancer,a complex and heterogeneous disease,arises from genomic instability.Currently,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical practice.However,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical demands.Metal nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer therapy.Their customizable physicochemical properties enable the development of targeted and personalized treatment platforms.In this review,we delve into the design principles and optimization strategies of metal nanoparticles.We shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal nanoparticles.These encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune response.Moreover,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle platforms.Finally,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

关 键 词：DNA damage Metal nanoparticles Nucleus-targeting DNA repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]