Electrospun nanofiber/hydrogel composite materials and their tissue engineering applications  

作　　者：Miaomiao Zhang Shixin Xu Ruoying Wang Yongan Che Cuicui Han Wei Feng Chengwei Wang Wen Zhao 

机构地区：[1]Key Laboratory for Space Biosciences and Biotechnology,School of Life Sciences,Northwestern Polytechnical University,Xi’an 710072,China

出　　处：《Journal of Materials Science & Technology》2023年第31期157-178,共22页材料科学技术（英文版）

基　　金：supported in part by the Key Research and Development Program of Shaanxi(No.2022SF-200);the Fund of Jiangsu Key Laboratory of Advanced Functional Polymers Design and Application in Soochow University(No.KJS2007).

摘　　要：Electrospun nanofiber/hydrogel composites combine the excellent biochemical properties of hydrogel with the biomimetic nature of electrospun fibers,and have attracted widespread attention in the last few years.Besides,nanofiber/hydrogel composites with tunable mechanical properties can mimic the microstructure of extracellular matrix(ECM)of various tissues and the microenvironment of different cells.These features enable electrospun fiber/hydrogel composites have uniquely advantageous for tissue repair.However,a comprehensive review of electrospun fiber/hydrogel composites as tissue engineering scaffolds is still lacking.Thus,this article systematically reviewed the preparation of electrospun fiber/hydrogel composites and their application in tissue engineering.First,the preparation strategies of electrospun fiber/hydrogel composites are classified and discussed.Second,the application of electrospun fiber/hydrogel-based scaffolds in tissue engineering,involving skin,blood vessel,nerve,bone and other tissue engineering,are summarized.Finally,future research directions for functional electrospun fiber/hydrogel scaffold materials are proposed.

关 键 词：ELECTROSPINNING HYDROGEL COMPOSITES SCAFFOLD Tissue engineering 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]