机构地区:[1]河北北方学院附属第一医院口腔科,河北张家口075000 [2]河北省张家口市口腔医院口腔科,河北张家口075000
出 处:《标记免疫分析与临床》2024年第2期264-269,共6页Labeled Immunoassays and Clinical Medicine
基 金:河北省医学科学研究课题(编号:20211453)。
摘 要:目的探讨血清趋化因子21(CCL21)、细胞因子样蛋白1(CYTL-1水平)与慢性牙周炎(CP)患者牙龈卟啉单胞菌(PG)感染及牙周临床指标的相关性。方法选取2019年6月至2023年5月在本院就诊的303例CP患者为实验组研究对象,并选取同期206例非CP患者作为对照组。根据CP患者病情严重程度分为轻度CP组(183例)、中度CP组(86例)、重度CP组(34例),分析患者一般资料及牙周指标的差异。检测血清中CCL21和CYTL-1表达水平。分析血清CCL21和CYTL-1表达水平与PG感染和牙周临床指标的相关性;采用ROC曲线分析CCL21和CYTL-1对CP的诊断价值。结果实验组PG的阳性率(68.32%)远高于对照组(17.96%)(P<0.05)。实验组中血清CCL21表达水平(270.82±33.77pg/mL)显著高于对照组(237.56±40.07pg/mL)(P<0.05),血清CYTL-1表达水平(174.41±29.85ng/mL)显著低于对照组(206.44±38.23ng/mL)(P<0.05)。随着CP患者病情的不断加重,PG的阳性率、血清CCL21表达水平和牙周指标呈现不同程度的上升趋势;而血清CYTL-1水平随着病情严重程度呈下降趋势(P<0.05)。CCL21表达水平与PG阳性感染和牙周指标均呈正相关(r=0.566、0.486、0.444、0.417、0.528,均P<0.05);CYTL-1表达水平与PG阳性感染和牙周指标均呈负相关(r=-0.584、-0.451、-0.433、-0.407、-0.456,均P<0.05);CCL21和CYTL-1两项者联合诊断CP结果优于任何一项单独分析(Z两项联合-CCL21=4.142,Z两项联合-CYTL-1=3.824;P<0.05)。结果CP患者血清中CCL21表达上调,CYTL-1表达下调与PG感染和牙周临床指标密切相关,且二者联合对CP有一定的诊断价值。Objective To investigate the correlation between serum levels of chemokine 21(CCL21)and cytokine like protein 1(CYTL-1)with porphyromonas gingivalis(PG)infection and periodontal clinical indicators in patients with chronic periodontitis(CP).Methods From June,2019 to May,2023,303 CP patients who visited our hospital were enrolled as the study subjects,while 206 non-CP patients were collected as the control group.CP patients were divided into the mild CP group(183 cases),moderate CP group(86 cases),and severe CP group(34 cases)based on the severity of their conditions.The differences in general information and periodontal indicators among groups were analyzed.The expression levels of CCL21 and CYTL-1 in serum were detected.The correlation between serum CCL21 and CYTL-1 expression levels and PG infection and periodontal clinical indicators was analyzed;ROC curve was drawn to analyze the diagnostic value of CCL21 and CYTL-1 for CP.Results The positive rate of PG in the experimental group(68.32%)was much higher than that in the control group(17.96%)(P<0.05).The expression level of serum CCL21 in the experimental group(270.82±33.77 pg/mL)was significantly higher than that in the control group(237.56±40.07 pg/mL)(P<0.05),while the expression level of serum CYTL-1(174.41±29.85 ng/mL)was significantly lower than that in the control group(206.44±38.23 ng/mL)(P<0.05).As the condition of CP patients continued to worsen,the positive rate of PG,the expression level of serum CCL21,and periodontal indicators showed varying degrees of upward trend;The level of serum CYTL-1 showed a decreasing trend with the worsen of disease(P<0.05).The expression level of CCL21 was positively correlated with PG positive infection and periodontal indicators(r=0.566,0.486,0.444,0.417,0.528,all P<0.05);The expression level of CYTL-1 was negatively correlated with PG positive infection and periodontal indicators(r=-0.584,-0.451,-0.433,-0.407,-0.456,all P<0.05);The combined diagnosis of CP by both CCL21 and CYTL-1 was superior to each individual-
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