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出　　处：《神经损伤与功能重建》2024年第4期F0004-F0004,共1页Neural Injury and Functional Reconstruction

摘　　要：Adenosine Receptors are the 0n-and-off Switch ofAstrocytic Cannabinoid Type 1(CB1)ReceptorEffect upon Synaptic Plasticity in the MedialPrefrontal Cortex Joana Goncalves-Ribeiro1,2Oksana K Savchak1,2Sara Costa-Pinto1,2Joana I Gomes1,2Rafael Rivas-Santisteban3,4Alejandro Lillo3,4Javier Sánchez Romero5,6Ana M Sebastio1,2Marta Navarrete5Gemma Navarro3,4,7Rafael Franco4,8,9Sandra H Vaz1,21.Instituto de Farmacologia e Neurociencias,Faculdade de Medicina,Universidade de Lisboa,Lisbon,Portugal.2.Instituto de Medicina Molecular Joao Lobo Antunes,Faculdade de Medicina,Universidade de Lisboa,Lisbon,Portugal.3.Department of Biochemistry and Physiology,School of Pharmacy and Food Science,Universitat de Barcelona,Barcelona Spain.4.CiberNed,Network Center for Neurodegenerative Diseases,National Spanish Health Institute Carlos II,Madrid,Spain.5.Instituto Cajal,CSIC,Madrid,Spain.6.PhD Program in Neuroscience,Universidad Autonoma de Madrid-Instituto Cajal,Madrid,Spain.7.Institut de Neurociencies,Universitat de Barcelona,Barcelona,Spain.8.Molecular Neurobiology Laboratory,Department of Biochemistry and Molecular Biomedicine,Faculty of Biology,Universitat de Barcelona,Barcelona,Spain.9.School of Chemistry,Universitat de Barcelona,Barcelona,Spain.Abstract The medial prefrontal cortex(mPFC)is involved in cognitive functions such as working memory.Astrocytic canna-binoid type 1 receptor(CB 1R)induces cytosolic calcium(Ca2+)concentration changes with an impact on neuronal function.mPFC astrocytes also express adenosine A1 and A2A receptors(A1 R,A2A R),being unknown the crosstalk between CB1R and adenosine receptors in these cells.We show here that a further level of regulation of astrocyte Ca^(2+)signaling occurs through CB1R-AzA R or CB1R-A1 R heteromers that ultimately impact mPFC synaptic plasticity.

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分 类 号：R-5[医药卫生]