不同级别胶质瘤患者MEK、ERK、CHKα蛋白的阳性表达情况及临床意义  

Positive expression and clinical significance of MEK,ERK and CHKαproteins in patients with glioma of different grades

作　　者：甘杰[1] 文擘彬 杨晗 王争[1] GAN Jie;WEN Bobin;YANG Han;WANG Zheng(Department of Neurosurgery,The Fourth Hospital of Changsha in Hunan Province,Changsha,Hunan 410000,China;Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan 410000,China)

机构地区：[1]湖南省长沙市第四医院神经外科,湖南长沙410000 [2]中南大学湘雅医院神经外科,湖南长沙410000

出　　处：《检验医学与临床》2024年第8期1118-1122,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨不同级别胶质瘤患者胆碱激酶α(CHKα)、细胞外信号调节激酶(ERK)及丝裂原激活蛋白激酶(MEK)蛋白的阳性表达情况及临床意义。方法回顾性分析2019年1月至2022年12月长沙市第四医院神经外科收治的124例胶质瘤患者的临床资料。检测、统计不同级别胶质瘤患者MEK、ERK、CHKα蛋白的阳性表达情况。结果不同肿瘤最大径、年龄、WHO分级及预后胶质瘤患者MEK、ERE、CHKα蛋白的高、低表达情况比较,差异均有统计学意义(P<0.05)。Ⅰ、Ⅱ、Ⅲ、Ⅳ级胶质瘤患者MEK蛋白阳性表达率分别为9.62%、7.69%、94.08%和92.04%,ERK蛋白阳性表达率分别为9.57%、7.49%、94.52%和92.18%,CHKα蛋白阳性表达率分别为9.60%、7.53%、94.71%和92.23%,高、低级别胶质瘤患者MEK、ERK、CHKα蛋白阳性表达率比较,差异均有统计学意义(P<0.05)。随访结束后结果显示,124例患者中死亡52例,失访12例,获得随访112例,随访率为90.32%。结论不同级别胶质瘤患者MEK、ERK、CHKα蛋白的阳性表达情况有明显区别,并且与患者的疾病预后明显相关,对疾病的诊断和预后判断具有重要价值。Objective To investigate the positive expression and clinical significance of choline kinaseα(CHKα),extracellular signal-regulated kinase(ERK)and mitogen-activated protein kinase(MEK)proteins in patients with different grades of glioma.Methods The clinical data of 124 glioma patients admitted to the Department of Neurosurgery,the Fourth Hospital of Changsha from January 2019 to December 2022 were retrospectively analyzed.The positive expressions of MEK,ERK and CHKαproteins in patients with glioma of different grades were detected and analyzed.Results The mortality risk of patients with glioma was statistically significant compared with the maximum diameter of different tumors,the age,WHO grade and prognosis of glioma patients with high and low expression of MEK,ERK and CHKαproteins(P<0.05).The positive expression rates of MEK protein in gradeⅠ,Ⅱ,ⅢandⅣgliomas were 9.62%,7.69%,94.08%and 92.04%respectively.The positive expression rates of ERK protein were 9.57%,7.49%,94.52%and 92.18%respectively.The positive expression rates of CHKαprotein were 9.60%,7.53%,94.71%and 92.23%respectively.There were significant differences in the positive expression rates of MEK,ERK and CHKαproteins between high and low grade patients with glioma(P<0.05).The follow-up results showed that 52 patients died,12 patients were lost to follow-up,and 112 patients were recovered,with a follow-up rate of 90.32%.Conclusion The positive expression of MEK,ERK and CHKαproteins in patients with glioma of different grades are significantly different,and are significantly correlated with the prognosis of the patients,which is of great value for the diagnosis and prognosis of the disease.

关 键 词：胶质瘤 丝裂原激活蛋白激酶 细胞外信号调节激酶 胆碱激酶α 免疫组织化学法 

分 类 号：R739.4[医药卫生—肿瘤]