微生态肠内营养支持对胃肠道恶性肿瘤根治术后化疗期患者营养状态、免疫功能、不良反应的影响  

Effects of microecological enteral nutrition support on nutritional status,immune function and adverse reactions in patients with radical resection of gastrointestinal malignancies during postoperative chemotherapy

作　　者：王丽 谢榜旗 陈玉华[1] WANG Li;XIE Bangqi;CHEN Yuhua(Department of the Second General Surgery and Gastroenterology,Nanyang Central Hospital,Nanyang,Henan 473000,China)

机构地区：[1]河南省南阳市中心医院普外科胃肠二区,河南南阳473000

出　　处：《检验医学与临床》2024年第8期1145-1148,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨微生态肠内营养支持对胃肠道恶性肿瘤(GIM)根治术后化疗期患者营养状态、免疫功能及不良反应的影响。方法选取2019年12月至2022年12月该院收治的110例GIM根治术后化疗期患者作为研究对象,随机分为常规营养组和微生态营养组,每组55例。常规营养组给予常规的肠内营养支持,微生态营养组给予微生态肠内营养支持。干预24周后,比较两组营养状态[血清清蛋白(ALB)、前清蛋白(PA)、血红蛋白(Hb)、营养风险筛查量表(NRS2002)评分和体质量指数(BMI)]、免疫功能(外周血CD4^(+)T淋巴细胞比例、CD8^(+)T淋巴细胞比例、CD4^(+)/CD8^(+))及干预期间不良反应(重度恶心呕吐、骨髓抑制、口腔感染)发生情况。结果干预后,微生态营养组ALB、PA、Hb水平、BMI、CD4^(+)T淋巴细胞比例、CD4^(+)/CD8^(+)均明显高于常规营养组,NRS2002评分、CD8^(+)T淋巴细胞比例均明显低于常规营养组,差异均有统计学意义(P<0.05);干预期间,微生态营养组重度恶心呕吐、骨髓抑制、口腔感染的发生率均低于常规营养组,差异均有统计学意义(P<0.05)。结论微生态肠内营养支持应用于GIM根治术后化疗期患者,能显著改善患者营养不良状态,减少不良反应发生,提升免疫功能,有助于改善患者的预后。Objective To investigate the effects of microecological enteral nutrition support on nutritional status,immune function and adverse reactions in patients with radical resection of gastrointestinal malignant tumor(GIM)during postoperative chemotherapy.Methods A total of 110 patients with radical resection of GIM admitted to this hospital from December 2019 to December 2022 were selected as the research objects,they were randomly divided into conventional nutrition group and microecological nutrition group,with 55 cases in each group.The conventional nutrition group was given routine enteral nutritional support,and the microecological nutrition group was given microecological enteral nutritional support.After 24 weeks of intervention,the nutritional status[serum albumin(ALB),prealbumin(PA),hemoglobin(Hb),Nutritional Risk Screening 2002(NRS2002)score and body mass index(BMI)],immune function(peripheral blood CD4^(+)T lymphocyte proportion,CD8^(+)T lymphocyte proportion,CD4^(+)/CD8^(+))and the incidence of adverse reactions(severe nausea and vomiting,bone marrow suppression,oral infection)during the intervention period were compared between the two groups.Results After the intervention,the levels of ALB,PA,Hb,BMI,CD4^(+)T lymphocyte ratio and CD4^(+)/CD8^(+)in the microecological nutrition group were significantly higher than those in the conventional nutrition group and the NRS2002 score and CD8^(+)T lymphocyte proportion in the microecological nutrition group were significantly lower than those in the conventional nutrition group(P<0.05).During the intervention period,the incidences of severe nausea and vomiting,bone marrow suppression and oral infection in the microecological nutrition group were lower than those in the conventional nutrition group,and the differences were statistically significant(P<0.05).Conclusion The application of microecological enteral nutrition support in postoperative radical resection of GIM patients during chemotherapy can significantly improve the malnutrition status of patients,reduce

关 键 词：微生态肠内营养 胃肠道恶性肿瘤 营养状态 免疫功能 不良反应 

分 类 号：R735.2[医药卫生—肿瘤]