帕金森病脑深部电刺激术微损毁效应的研究进展  

Progress in Microlesion Effects of Deep Brain Stimulation in Parkinson’s Disease

作　　者：李涛[1] 金凤 殷肖雪 梁战华[1] LI Tao;JIN Feng;YIN Xiao-xue;LIANG Zhan-hua(Department of Neurology,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China)

机构地区：[1]大连医科大学附属第一医院神经内科,大连116011

出　　处：《中国临床神经科学》2024年第1期99-103,共5页Chinese Journal of Clinical Neurosciences

基　　金：国家重点研发计划项目子课题(编号:2016YFC0105904DLL);辽宁省省直医院改革重点临床科室诊疗能力建设项目(编号:LNCCC-C06-2015);辽宁省教育厅基本科研项目(编号:LJKMZ20221277)。

摘　　要：脑深部电刺激疗法可显著改善帕金森病患者的运动症状。对于专科医生而言,微损毁效应虽众所周知,但在多数文献只是简短提及。少数研究经过充分设计将其作为主要研究指标并对该现象进行定性和定量分析,但其潜在机制仍有广阔研究空间和价值。文中旨在对帕金森病脑深部电刺激术相关的微损毁效应进行系统全面的归纳总结,提高对该现象的认识。Deep brain stimulation(DBS)therapy can significantly improve motor symptoms and the quality of life in PD patients.For physicians in the field of neuromodulation of movement disorders,the microlesion effect(MLE),although well known,is only briefly mentioned in most literature.A few studies have been adequately designed to use it as a primary research indicator and to conduct qualitative and quantitative analysis of the phenomenon but the potential mechanism still has broad space and value research.A systematic and comprehensive overview of MLE was provided to improve the understanding of the phenomenon.

关 键 词：帕金森病 脑深部电刺激 微损毁效应 

分 类 号：R742.5[医药卫生—神经病学与精神病学]