联合恩他卡朋治疗帕金森病时左旋多巴的剂量探究  

Dosage Exploration of Levodopa in Combined Entacapone Therapy for Parkinson's Disease

作　　者：罗继本 林世奇 贾鑫 赵毅 LUO Jiben;LIN Shiqi;JIA Xin;ZHAO Yi(Department of Neurosurgery,Guiyang Second People's Hospital,Guiyang,Guizhou Province,550000 China)

机构地区：[1]贵阳市第二人民医院神经外科,贵州贵阳550000

出　　处：《中外医疗》2024年第4期99-102,共4页China & Foreign Medical Treatment

摘　　要：目的探讨临床治疗帕金森病(Parkinson's Disease,PD)联合恩他卡朋时左旋多巴的剂量研究。方法便利选取2021年1月-2023年1月于贵阳市第二人民医院治疗的68例PD患者为研究对象,根据治疗时左旋多巴的剂量分为观察组和对照组,每组34例。观察组患者采用恩他卡朋联合左旋多巴(250 mg/次)治疗,对照组患者采用恩他卡朋联合左旋多巴(350 mg/次)治疗。比较两组临床疗效、统一帕金森病评定量表评分、炎性反应指标、氧化应激指标及不良反应。结果观察组临床疗效高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者的统一帕金森病评定量表评分均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。治疗后两组患者的炎性反应指标均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。治疗后两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论小剂量的左旋多巴联合恩他卡朋治疗PD的临床效果显著,可以有效改善PD症状和提高患者的日常生活能力,改善炎性反应指标和氧化应激反应,不会增加不良反应。Objective To investigate the dose of levodopa in the clinical treatment of Parkinson's disease(PD)combined with entacapone.Methods 68 PD patients treated in Guiyang Second People's Hospital from January 2021 to January 2023 were conveniently selected as the study objects and were divided into observation group and control group according to the dose of levodopa during treatment,with 34 cases in each group.Observation group was treated with entacapone combined with levodopa(250 mg/time),control group was treated with entacapone combined with le-vodopa(350 mg/time).The clinical efficacy,unified Parkinson's Disease Rating Scale score,inflammatory response index,oxidative stress index and adverse reaction were compared between the two groups.Results The clinical effi-cacy of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the unified Parkinson's disease rating scale scores of both groups were decreased,and the observation group was lower than the control group,the differences were statistically significant(all P<0.05).After treatment,the inflammatory response indexes of both groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(all P<0.05).There was no significant difference in the in-cidence of adverse reactions between the two groups after treatment(P>0.05).Conclusion The clinical effect of small-dose levodopa combined with entacapone in the treatment of PD is remarkable,which can effectively improve the symptoms of PD and improve the patients'ability of daily life,improve the index of inflammatory response and oxida-tive stress,and will not increase the adverse reactions.

关 键 词：帕金森病 恩他卡朋 左旋多巴 氧化应激 炎性反应 

分 类 号：R742.5[医药卫生—神经病学与精神病学]