阴极经颅直流电刺激治疗急性期脑卒中的效果及对神经功能的影响  

Effect of Cathodic Transcranial Direct Current Stimulation on Acute Phase Stroke and Its Influence on Neurological Function

作　　者：宋大伟 于红日 SONG Dawei;YU Hongri(Department of Neurology,Rushan People's Hospital,Rushan 264500,China;不详)

机构地区：[1]乳山市人民医院神经内科,山东乳山264500 [2]乳山市人民医院心内科,山东乳山264500

出　　处：《中国医学创新》2024年第10期47-51,共5页Medical Innovation of China

摘　　要：目的:探究阴极经颅直流电刺激治疗急性期脑卒中的效果,及对神经功能的影响。方法:在2019年9月—2021年9月展开此次研究,选取此期间在乳山市人民医院接受治疗的急性期脑卒中患者82例,应用随机数表法将其分为对照组(n=41)及观察组(n=41)。对照组接受常规康复训练,观察组在对照组基础上加用阴极经颅直流电刺激治疗。对比两组运动功能[Fugl-Meyer评估表(FMA)、上肢动作研究量表(ARAT)]、日常生活能力[改良Barthel指数(MBI)]、神经功能缺损情况及认知功能[神经功能缺损程度评分(NDS)、欧洲脑卒中量表(ESS)、蒙特利尔认知评估量表(MoCA)]、炎症因子[超敏C反应蛋白(hs-CRP)、超氧化物歧化酶(SOD)、白介素-10(IL-10)、丝氨酸蛋白酶抑制物]、神经因子[缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)、脑源性神经营养因子(BNDF)]。结果:治疗前,两组FMA、ARAT、MBI评分比较,差异均无统计学意义(P>0.05);治疗后,两组FMA、ARAT、MBI评分均升高,且观察组均高于对照组(P<0.05)。治疗前,两组NDS、ESS、MoCA评分比较,差异均无统计学意义(P>0.05);治疗后,两组NDS评分均降低,观察组低于对照组,两组MoCA、ESS评分均升高,观察组均高于对照组(P<0.05)。治疗前,两组hs-CRP、SOD、IL-10、丝氨酸蛋白酶抑制剂水平比较,差异均无统计学意义(P>0.05);治疗后,两组hs-CRP、IL-10水平均降低,观察组均低于对照组,两组SOD、丝氨酸蛋白酶抑制剂水平均升高,观察组均高于对照组(P<0.05)。治疗前,两组HIF-1α、VEGF、BNDF水平比较,差异均无统计学意义(P>0.05);治疗后,两组HIF-1α水平均降低,观察组低于对照组,两组VEGF、BNDF水平均升高,观察组均高于对照组(P<0.05)。结论:急性期脑卒中患者接受阴极经颅直流电刺激治疗,可改善神经功能缺损,提高运动功能,减轻炎症反应,提高患者认知能力。Objective:To investigate the effect of cathodic transcranial direct current stimulation on acute phase stroke and its influence on neurological function.Method:The study was conducted from September 2019 to September 2021.A total of 82 patients with acute phase stroke who received treatment in Rushan People's Hospital during this period were selected and divided into control group(n=41)and observation group(n=41)according to random number table method.The control group received routine rehabilitation training,and the observation group was treated with cathodic transcranial direct current stimulation on the basis of control group.The motor function[Fugl-Meyer assessment(FMA),action research arm test(ARAT)],ability of daily living[modified Barthel index(MBI)],neural function deficient situation and cognitive function[neural function deficient scale(NDS),European stroke scale(ESS)and Montreal cognitive assessment(MoCA)],inflammatory factors[hypersensitive C reactive protein(hs-CRP),superoxide dismutase(SOD),interleukin-10(IL-10),serine protease inhibitor],neuro factors[hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF),brain derived neurotrophic factor(BNDF)]were compared between the two groups.Result:Before treatment,there were no significant differences in FMA,ARAT and MBI scores between the two groups(P>0.05).After treatment,FMA,ARAT and MBI scores of both groups were increased,and those in the observation group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences in Medical Innovation of China Vol.21,No.10 April,2024 NDS,ESS and MoCA scores between the two groups(P>0.05).After treatment,the NDS scores of both groups were decreased,that in the observation group was lower than that in the control group,the MoCA and ESS scores of both groups were increased,and those in the observation group were higher than those in the control group(P<0.05).Before treatment,there were no significant differences in the levels of hs-CRP,SOD,IL-10 and s

关 键 词：阴极经颅直流电刺激 急性期 脑卒中 认知功能 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]