辣椒素受体在腹泻型肠易激综合征发病中的作用  

Role of capsaicin receptors in pathogenesis of diarrheal irritable bowel syndrome

作　　者：崔筱 刘亮 Cui Xiao;Liu Liang(Graduate School,Shandong First Medical University,Shandong Academy of Medical Sciences,Jinan 250011,China;Department of Gastroenterology,Central Hospital Affiliated to Shandong First Medical University,Jinan 250011,China)

机构地区：[1]山东第一医科大学研究生院山东省医学科学院,济南250011 [2]山东第一医科大学附属中心医院消化内科,济南250011

出　　处：《国际医药卫生导报》2024年第7期1066-1070,共5页International Medicine and Health Guidance News

基　　金：山东省医药卫生科技发展计划(202003030878)。

摘　　要：腹泻型肠易激综合征(diarrheal irritable bowel syndrome,IBS-D)是常见的功能性胃肠疾病之一,其典型症状为间断性腹痛、腹泻。IBS-D有病程长、症状易反复等特点,是一种严重影响患者生活质量的慢性功能性疾病。目前,研究认为,其发病机制与内脏高敏感、脑-肠轴失衡、肠道菌群失调等因素相关。有研究表明,辣椒素受体参与其中并发挥了重要作用。本文就辣椒素受体参与内脏高敏感、脑-肠轴失衡、肠道菌群失调发生的具体机制作一综述,以期为探索IBS-D发病机制及治疗靶点提供参考。Diarrheal irritable bowel syndrome(IBS-D)is one of the common functional gastrointestinal disorders characterized by intermittent abdominal pain and diarrhea.IBS-D is a chronic functional disease with a long course and easy recurrence of symptoms,and seriously affects the patients'quality of life.At present,it is believed that its pathogenesis is closely related to factors such as visceral hypersensitivity,brain-gut axis imbalance,intestinal flora imbalance,etc.Current studies have shown that capsaicin receptors are involved and play an important role.In this article,the specific mechanism of capsaicin receptors involved in visceral hypersensitivity,brain-gut axis imbalance,and intestinal flora imbalance is reviewed,so as to provide references for exploring the pathogenesis and therapeutic targets of IBS-D.

关 键 词：腹泻型肠易激综合征 辣椒素受体 内脏高敏感 脑-肠轴 肠道菌群 综述 

分 类 号：R574.4[医药卫生—消化系统]