m^(6)A及m^(5)C甲基化修饰通过促进细胞增殖与转移影响癌症的发生和发展  

m^(6)A and m^(5)C methylation modification affects the initiation and development of cancers byregulating cellular proliferation and metastasis

作　　者：邵爽 郭纪伟 孟玮[1] Shao Shuang;Guo Jiwei;Meng Wei(Medical Research Center,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院医学研究中心,滨州256600

出　　处：《国际医药卫生导报》2024年第8期1316-1320,共5页International Medicine and Health Guidance News

基　　金：山东省高等学校“青创科技计划”(2020KJK002);“齐鲁卫生与健康杰出青年人才”项目。

摘　　要：在RNA中已经发现了170多种化学修饰,RNA甲基化修饰是一个重要的转录后修饰过程,N6-甲基腺苷(m^(6)A)和5-甲基胞嘧啶(m^(5)C)普遍存在于真核生物和原核生物中,使得RNA甲基化在调控基因表达进而影响细胞生物活性的研究越来越受到重视。与细胞增殖和转移有关的信号通路调控肿瘤免疫、代谢等细胞活动,并在调节器官大小、组织再生和干细胞自我更新中起着关键作用,影响癌症的发生和发展。在本综述中,我们讨论m^(6)A及m^(5)C甲基化修饰通过一些热门通路调控癌症的发生和发展,这为我们从RNA甲基化的角度理解疾病和寻找新的治疗方法提供了新的理论基础。So far,more than 170 chemical modifications have been found in RNA.RNA methylation modification is an important post-transcriptional regulation process.N6-methyladenosine(m^(6)A)and 5-methylcytosine(m^(5)C)are ubiquitous in eukaryotes and prokaryotes.Additionally,more and more attention has been paid to the exploration of RNA methylation within regulating gene expression and regulating the cellular biological activity in thetumor cells.Furthermore,some known cell signal pathways involved in cellular proliferation andmetastasis are closely related to cancers immunity and metabolic regulation,and these signalpathways play an important role in regulating organ size,tissue regeneration,and stem cellself-renewal,which ultimately affects the initiation and development of tumors.In this review,wediscuss that the m^(6)A and m^(5)C methylation regulate the occurrence and development of cancersthrough some popular pathways in human cancers,which provides a new theoretical basis forunderstanding and seeking new therapeutic disease approaches.

关 键 词：RNA甲基化修饰 信号通路 N6-甲基腺苷 5-甲基胞嘧啶 癌症发生和发展 进展 

分 类 号：R730.2[医药卫生—肿瘤]