Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis  

作　　者：ZHENG Ting WANG Ying LI Xianming LI Chenghui WU Peng 

机构地区：[1]Analytical&Testing Centre,State Key Laboratory of Hydraulics and Mountain River Engineering,Sichuan University,Chengdu,610064,P.R.China [2]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,453007,P.R.China [3]Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu,610064,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第2期213-224,共12页高等学校化学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22325403);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University,China(No.2022A02).

摘　　要：Accurate detection of biomarkers is essential for disease diagnosis.Although the highly sensitive fluorescence probes are feasible for the above goal,it is typically interfered by the auto-fluorescence and light scattering of the biological samples.Photochemical afterglow system(consisting of photosensitizer,afterglow substrate and emitter)based on cascade photochemical reactions exhibits long-lived luminescence(seconds to hours),thus avoiding background interference.With the assistance of polymers,such as polystyrene microspheres,the photochemical afterglow systems have been transformed into homogeneous and water-soluble nanoparticles,and used for in-vitro biomarker analysis.Here,we summarized the principle,preparation and applications of these afterglow nanoparticles,and evaluated their performance in clinical sample testing by comparing with other nanoparticle-based methods.Finally,several problems and possible solutions of afterglow nanoparticle-based methods in biomarker determination were also mentioned.

关 键 词：Photochemical afterglow In-vitro analysis Background-free detection BIOMARKER 

分 类 号：O63[理学—高分子化学]