Fluorescent Probes for Cysteine and Cysteine Oxidation Imaging  

作　　者：ZHANG Xia LI Guocheng PAN Wei LI Na LI Yanhua TANG Bo 

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Key Laboratory of Molecular and Nano Probes,Ministry of Education,Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong,Institute of Molecular and Nano Science,Shandong Normal University,Jinan,250014,P.R.China [2]Laoshan Laboratory,Qingdao,266237,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第2期225-236,共12页高等学校化学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22374092,22206117);the Project of Shandong Provincial Laboratory,China(No.SYS202207);the Youth Innovation Science and Technology Program of Higher Education Institution of Shandong Province,China(No.2021KJ030);the Fund of the Jinan Innovation Team,China(No.2021GXRC034);the Natural Science Foundation of Shandong Province,China(No.ZR2021QB147).

摘　　要：Cysteine is an important regulator of redox processes.Due to the nucleophilic and oxidative sensitivity,cysteine residues in proteins can be oxidized by intracellular reactive oxygen species(ROS),which can lead to protein structural and functional changes.Hence,the development of fluorescent probes to image cysteine and cysteine oxidation is of great significance for the study of redox homeostasis in living system.In this review,the development of fluorescent probes for imaging cysteine and cysteine oxidation was summarized.Moreover,we further analyzed defects of the reported fluorescent probes and made suggestions for the future development of fluorescent probes.We expect that this review can not only provide a deeper understanding of the role of cysteine and cysteine oxidation in oxidative stress,but also broaden the application of fluorescent probes in imaging cysteine and cysteine oxidation.

关 键 词：CYSTEINE Cysteine oxidation Fluorescent probe Oxidative stress 

分 类 号：O657.3[理学—分析化学]