Neuroimaging and neuroendocrine insights into foodcravings and appetite interventions in obesity  

作　　者：Jin Huang Chen Wang Hang-Bin Zhang Hui Zheng Tao Huang Jian-Zhong Di 

机构地区：[1]Department of Metabolic&Bariatric Surgery,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China [2]Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Centre for Mental Disorders,Shanghai Mental Health Centre,Shanghai Jiao Tong Univ ersity Sc hool of Medicine,Shanghai 200030,China [3]Xuhui Health Care Commission,Shanghai 200030,China

出　　处：《Psychoradiology》2023年第1期95-106,共12页精神影像学（英文）

基　　金：supported by the National Natural Science Foundation of China (82370901);Shanghai Health Commission project (no.20214098);Shanghai Science and Technology Committee project (no.22dz1204700);National Science and Technology Major Project of the Ministry of Science and Technology of China (no.2022YFC2407004);Shanghai Xuhui District Smart Medicine (no.XHZH202111).

摘　　要：This article reviews the previous studies on the distinction between food cravings and appetite,and how they are regulated by hor-mones and reflected in brain activity.Based on existing research,food cravings are defined as individual preferences influenced by hormones and psychological factors,which differ from appetite,as they are not necessarily related to hunger or nutritional needs.The article also evaluates the neuroimaging findings about food cravings,and interventions to reduce food cravings,such as mindfulness training,alternative sweeteners,non-invasive brain stimulation techniques,cognitive-behavioral therapy,and imaginal retraining,and points out their advantages,disadvantages,and limitations.Furthermore,the article delves into the potential future directions in the field,emphasizing the need for a neuroendocrine perspective,considerations for associated psychiatric disorders,innovative clinical interventions,and emerging therapeutic frontiers in obesity management.The article outlines the neuro-endocrine basis of food cravings,including ghrelin,leptin,melanocortin,oxytocin,glucagon-like peptide-1,baclofen,and other hormones and their brain regions of action.The article argues that food cravings are an important target for obesity,and more research is needed to explore their complex characteristics and mechanisms,and how to effectively interact with their neuro-endocrine pathways.The article provides a new perspective and approach to the prevention and treatment of obesity.

关 键 词：food cravings fMRI APPETITE OBESITY neuro-endocrine 

分 类 号：R589.2[医药卫生—内分泌]