Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity  

作　　者：Qi Liu Xinwei Song Xinqi Zhou Linghong Huang Xiaodong Zhang Lan Wang Siyu Zhu Chunmei Lan Wenxu Yang Weihua Zhao 

机构地区：[1]The Center of Psychosomatic Medicine,Sichuan Provincial Center for Mental Health,Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China,Chengdu 611731,China [2]Institute of Brain and Psychological Sciences,Sichuan Normal University,Chengdu 610066,China [3]Chengdu Women's and Children's Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China [4]Institute of Electronic and Information Engineering of UESTC in Guangdong,Dongguan 523808,China

出　　处：《Psychoradiology》2023年第1期162-170,共9页精神影像学（英文）

基　　金：supported by the Fundamental Research Funds for the Central Universities,UESTC[grant number ZYGX2020J027-WHZ];Natural Science Foundation of sichuan Province[grant number 2022NSFSC1375-WHZ];Guangdong Basic and Applied Basic Research Foundation[grant number 2021A1515110511-WHZ];Sichuan Science and Technology Program[grant number 2020YFS0484 WXY].

摘　　要：Background:Childhood maltreatment(CM)is a potential risk factor for some neuropsychiatric disorders in adulthood(e.g.depression and anxiety)and alters trajectories of brain development.Accumulating evidence suggests that functional connectivity of the limbic system,especially the amygdala,is highly associated with childhood maltreatment,although not all studies have found this.These inconsistent results may be due to differential alterations of amygdala resting-state functional connectivity(rsFC)following childhood maltreatment.Objective:Our aim was to investigate the relationship between the rsFC of amygdala subregions and CM severity,as well as to develop a stable rsFC-based model for inferring the severity of CM.Methods:In this study,we employed the Childhood Trauma Questionnaire(CTQ)to assess CM severity in each individual.We explored the relationship between the rsFC of amygdala subregions(i.e.centromedial-CMA,basolateral-BLA,superficial-SFA amygdala)and CM experience in a discovery dataset of n=110 healthy Chinese participants by linear multiple regression analysis.Subsequent dimensional and categorical approach were performed to elucidate the relationship between rsFCs and CM severity and CM subtypes,respectively.A support vector regression model was then conducted to validate the associations between rsFCs and total CTQ scores.Moreover,we also verified the model into another independent replication dataset(n=38).Results:Our findings suggested that childhood maltreatment was negatively associated with rsFC between the right superficial amyg-dala and perigenual anterior cingulate cortex(pgACC)/postcentral gyrus(PCG)but not the other two amygdala subregions.Moreover,SFA-pgACC coupling was more associated with physical neglect whereas the SFA-PCG was more related to emotional neglect.In addi-tion,supervised machine learning confirmed that using these two rsFCs as predictors could stably estimate continuous maltreatment severity in both discovery and replication datasets.Conclusion:The current study supports t

关 键 词：Childhood maltreatment Amygdala subregions Superficial amygdala Resting-state functional connectivity NEGLECT 

分 类 号：R749[医药卫生—神经病学与精神病学]