Neural substrates of behavioral inhibitory control during the two-choice oddball task:functional neuroimaging evidence  

作　　者：Shirui Zhao Ruosong Yuan Wei Gao Qiang Liu Jiajin Yuan 

机构地区：[1]The Affect Cognition and Regulation Laboratory(ACRLab),Institute of Brain and Psychological Sciences,Sichuan Normal University,Chengdu 610066,China [2]Faculte des Sciences Psychologiques et de 1'Education,Universite Libre de Bruxelles(ULB)Brussels 1050,Belgium [3]Faculty of Psychology Southwest University,Chongqing 400715,China [4]Sichuan Key Laboratory of Psychology and Behavior of Discipline Inspection and Supervision(Sichuan Normal University),Chengdu 610066,China

出　　处：《Psychoradiology》2023年第1期203-212,共10页精神影像学（英文）

基　　金：supported by the national natural science foundation of China (NSFC31971018);Sichuan distinguished young scholar fund (2023NSFSC1938).

摘　　要：Background:Behavioral inhibitory control(BIC)depicts a cognitive function of inhibiting inappropriate dominant responses to meet the context requirement.Despite abundant research into neural substrates of BIC during the go/no-go and stop signal tasks,these tasks were consistently shown hard to isolate neural processes of response inhibition,which is of primary interest,from those of response generation.Therefore,it is necessary to explore neural substrates of BIC using the two-choice oddball(TCO)task,whose design of dual responses is thought to produce an inhibition effect free of the confounds of response generation.Objective:The current study aims at depicting neural substrates of performing behavioral inhibitory control in the two-choice oddball task,which designs dual responses to balance response generation.Also,neural substrates of performing BIC during this task are compared with those in the go/no-go task,which designs a motor response in a single condition.Methods:The present study integrated go/no-go(GNG)and TCO tasks into a new Three-Choice BIC paradigm,which consists of stan-dard(75%),deviant(12.5%),and no-go(12.5%)conditions simultaneously.Forty-eight college students participated in this experiment,which required them to respond to standard(frequent)and deviant stimuli by pressing different keys,while inhibiting motor response to no-go stimuli.Conjunction analysis and ROI(region of interest)analysis were adopted to identify the unique neural mechanisms that subserve the processes of BIC.Results:Both tasks are effective in assessing BIC function,reflected by the significantly lower accuracy of no-go compared to standard condition in GNG,and the significantly lower accuracy and longer reaction time of deviant compared to standard condition in TCO.However,there were no significant differences between deviant and no-go conditions in accuracy.Moreover,functional neuroimaging has demonstrated that the anterior cingulate cortex(ACC)activation was observed for no-go vs.standard contrast in the GNG task,but

关 键 词：behavioral inhibitory control two-choice oddball go/no-go FMRI 

分 类 号：R741[医药卫生—神经病学与精神病学]