Sex differences of brain cortical structure in major depressive disorder  

作　　者：Jingping Mou Ting Zheng Zhiliang Long Lan Mei Yuting Wang Yizhi Yuan Xin Guo Hongli Yang Qiyong Gong Lihua Qiu 

机构地区：[1]Department of Radiology.the Second People's Hospital of Yibin,Ybin 644000,China [2]Department of Radiology,the Affiliated Hospital of Southwest Medical University,Luzhou 646000,China [3]Department of Radiology,the First People's Hospital of Yibin,Yibin 644000,China [4]Sleep and Neurolmaging Center,Faculty of Psychology,Southwest University,Chongqing 400715,China [5]Huaxi MR Research Center(HMRRC),West China Hospital of Sichuan University,Chengdu 610041,China [6]Research Center of Neuroimaging big data,the Second People's Hospital of Yibin,Yibin 644000,China

出　　处：《Psychoradiology》2023年第1期213-219,共7页精神影像学（英文）

基　　金：supported by the Sichuan Science and Technology Program (No.2018JY0666);58th batch Chinese Postdoctoral Science Foundation (No.2015M582554);sichuan Provincial Health and Family Planning Commission (No.150251);Science and Technology Bureau of Yibin city (No.2015SF030);Open Project of Sichuan Key Laboratory of Functional and Molecular Imaging (No.SCU-HM-2021001);Project of Health Commission of Yibin city (No.2020YW085);Xinglin Scholar Project of Chengdu University of Taditional Chinese Medicine (No.YYZX2020111).

摘　　要：Background:Major depressive disorder(MDD)has different clinical presentations in males and females.However,the neuroanatom-ical mechanisms underlying these sex differences are not fully understood.Objective:The purpose of present study was to explore the sex differences in brain cortical thickness(CT)and surface area(SA)of MDD and the relationship between these differences and clinical manifestations in different gender.Methods:High-resolution T1-weighted images were acquired from 61 patients with MDD and 61 healthy controls(36 females and 25 males,both).The sex differences in CT and SA were obtained using the FreeSurfer software and compared between every two groups by post hoc test.Spearman correlation analysis was also performed to explore the relationships between these regions and clinical characteristics.Results:In male patients with MDD,the CT of the right precentral was thinner compared to female patients,although this did not survive Bonferroni correction.The SA of several regions,including right superior frontal,medial orbitofrontal gyrus,inferior frontal gyrus triangle,superior temporal,middle temporal,lateral occipital gyrus,and inferior parietal lobule in female patients with MDD was smaller than that in male patients(P<0.01 after Bonferroni correction).In female patients,the SA of the right superior temporal(r=0.438,P=0.008),middle temporal(r=0.340,P=0.043),and lateral occipital gyrus(r=0.372,P=0.025)were positively correlated with illness duration.Conclusion:The current study provides evidence of sex differences in CT and SA in patients with MDD,which may improve our understanding of the sex-specific neuroanatomical changes in the development of MDD.

关 键 词：major depressive disorder gender differences magnetic resonance imaging cortical thickness surface area 

分 类 号：R749.4[医药卫生—神经病学与精神病学]