Sex dimorphic cortical brain volumes associated with antisocial behavior in young adults  

作　　者：Ke Ding Miao Xu Taicheng Huang Yiying Song Feng Kong Zonglei Zhen 

机构地区：[1]School of Psychology,Shenzhen University,Shenzhen 518060,China [2]Beijing Key Laboratory of Applied Experimental Psychology,Faculty of Psychology,Beijing Normal University,Beijing,China,State Key Laboratory of Cognitive Neuroscience and Learning&IDG/McGovern Institute for Brain Research,Beijing Normal University,Beijing 100875,China [3]Department of Psychology and Tsinghua Laboratory of Brain and Intelligence,Tsinghua University,Beijing 100084,China [4]School of Psychology,Shaanxi Normal University,Xi’an 710119,China

出　　处：《Psychoradiology》2023年第1期276-284,共9页精神影像学（英文）

基　　金：funded by the National Natural Science Foun-dation of China (31861143039,31872786);the National Basic Research Program of China (2018YFC0810602);Changiang Scholars Programme of China.

摘　　要：Background:Although sex differences in antisocial behavior are well-documented,the extent to which neuroanatomical differences are related to sex differences in antisocial behavior is unclear.The inconsistent results from different clinical populations exhibiting antisocial behaviors are mainly due to the heterogeneity in etiologies,comorbidity inequality,and small sample size,especially in females.Objective:The study aimed to find sexual dimorphic brain regions associated with individual differences in antisocial behavior while avoiding the issues of heterogeneity and sample size.Methods:We collected structural neuroimaging data from 281 college students(131 males,150 females)and analyzed the data using voxel-based morphometry.Results:The gray matter volume in three brain regions correlates with self-reported antisocial behavior in males and females differ-ently:the posterior superior temporal sulcus,middle temporal gyrus,and precuneus.The findings have controlled for the total cortical gray matter volume,age,IQ,and socioeconomic status.Additionally,we found a common neural substrate of antisocial behavior in both males and females,extending from the anterior temporal lobe to the insula.Conclusion:This is the first neuroanatomical evidence from a large non-clinical sample of young adults.The study suggests that differences in males and females in reading social cues,understanding intentions and emotions,and responding to conflicts may contribute to the modulation of brain morphometry concerning antisocial behavior.

关 键 词：antisocial behavior sex differences magnetic resonance imaging voxel-based morphometry 

分 类 号：R742[医药卫生—神经病学与精神病学]