营养状态对肺腺癌患者接受免疫联合化学治疗疗效及不良反应的影响  

Effects of nutritional status on the efficacy and adverse reactions of lung adenocarcinoma patients receiving immunotherapy combined with chemotherapy

作　　者：包文庭[1] 张道明 郑永法[1] BAO Wenting;ZHANG Daoming;ZHENG Yongfa(Cancer Center,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院肿瘤中心,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2024年第3期311-315,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:81703035)。

摘　　要：目的:探究营养状态对免疫联合化学治疗肺腺癌患者疗效及不良反应的影响。方法:回顾性分析武汉大学人民医院肿瘤中心接受免疫联合化学治疗的肺腺癌患者65例,根据NRS2002将患者分为无营养风险组(A组)和营养风险组(B组)。对比两组的近期疗效、治疗期间的不良反应以及生活质量。结果:纳入患者中,无营养风险组32例,营养风险组33例。A组治疗疗效优于B组(P<0.05),营养状态及体质量指数(BMI)是治疗疗效的显著影响因素。A组患者2级及以上皮肤毒性、胃肠道毒性的发生率明显低于B组患者(P<0.05)。生活质量方面,A组的躯体功能、角色功能、情感功能评分均高于B组(P<0.05)。结论:良好的营养状态有助于减轻接受免疫联合化学治疗肺癌患者的毒副反应,同时有利于改善生活质量,可能是疗效获益的有利因素。Objective:To explore the effects of nutritional status on the efficacy and adverse reactions of lung adenocarcinoma patients treated with immunotherapy combined with chemotherapy.Methods:Sixty⁃five patients with lung adenocarcinoma who received immunotherapy combined with chemotherapy in the cancer center of Renmin Hospital of Wuhan University were retrospectively ana⁃lyzed.According to NRS2002,the patients were divided into the non⁃nutritional risk group(group A)and the nutritional risk group(group B).Short⁃term efficacy,adverse reactions during treatment,and quality of life were compared between the two groups.Results:Among the included patients,32 cases were in the non⁃nutritional risk group and 33 cases were in the nutritional risk group.The thera⁃peutic effect of combined immunotherapy in group A was better than that in group B(P<0.05).Nu⁃tritional status and body mass index(BMI)were significant influencing factors of therapeutic efficacy.The incidence of grade 2 and above dermal toxicity and gastrointestinal toxicity in group A was signifi⁃cantly lower than that in group B(P<0.05).In terms of quality of life,the scores of physical func⁃tion,role function,and emotional function in group A were higher than those in group B(P<0.05).Conclusion:A good nutritional status helps to alleviate the toxic and side effects in lung cancer pa⁃tients receiving immunotherapy combined with chemotherapy,and it also contributes to improving the quality of life.It may be a favorable factor for the beneficial effects of treatment.

关 键 词：免疫治疗 营养状态 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]