肿瘤抑制蛋白PDCD4结构特性与疾病关系解析及研究进展  

Progress on the relationship between tumor suppressor PDCD4 and diseases based on the analysis of structural characteristics

作　　者：李卉 吴光明 Hui Li;Guangming Wu(Chongqing College of Electronic Engineering,Smart Health College,Chongqing 401331,China;The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China;Division of Basic Research,Guangzhou National Laboratory,Guangzhou 510005,China)

机构地区：[1]重庆电子工程职业学院智慧健康学院,重庆401331 [2]广州医科大学附属第三医院,广州510150 [3]广州国家实验室基础研究部,广州510005

出　　处：《遗传》2024年第4期290-305,共16页Hereditas（Beijing)

基　　金：国家自然科学基金项目(编号:31801181);重庆市自然科学基金面上项目(编号:cstc2020jcyj-msxmX0903);重庆电子工程职业学院科研项目(编号:22XJDXWT35)资助。

摘　　要：程序性细胞死亡蛋白PDCD4(programmed cell death 4)是一种肿瘤抑制蛋白,在多种肿瘤组织中下调并提示不良预后,是第一种被发现通过抑制翻译抵抗肿瘤转化、侵袭和转移的蛋白质。PDCD4自身结构与功能关系密切,并受细胞外信号影响,其蛋白表达水平和功能与人体两大信号通路PI3K-Akt-mTOR和MAPK密切相关,通过多种机制调节与肿瘤相关的其他蛋白质。本文通过解析PDCD4结构、功能与疾病的关系,总结了近年来PDCD4在凋亡、自噬、肿瘤、炎症等生理过程和疾病中的作用,为PDCD4及相关蛋白的信号传导路径研究和以它们为靶标的疾病治疗提供启发和思路。The tumor suppressor programmed cell death 4(PDCD4)is downregulated in various tumor tissues indicating poor prognosis.PDCD4 is the first protein found to resist tumor transformation,invasion,and metastasis by inhibiting translation.The functions of PDCD4 dependent on its structures are affected by extracellular signals.It regulates tumor-related proteins through a variety of mechanisms,especially involved in two major signaling pathways,PI3K-Akt-mTOR and MAPK.By analyzing the relationship between the structures,functions and diseases of PDCD4,this review summarizes the roles of PDCD4 in several physiological processes and diseases such as apoptosis,autophagy,tumor,and inflammation in recent years,thereby providing insights for the study of the signaling pathways of PDCD4 and related proteins and the treatment of diseases targeting them.

关 键 词：PDCD4 翻译抑制 肿瘤 结构元件 功能 

分 类 号：R730.2[医药卫生—肿瘤]