交联密度对五层共挤输液用膜性能的影响  

Effect of Crosslinking Density on the 5-Layer Co-extrusion Film for Infusion

作　　者：吴熊 杨静 魏七一 徐赛 宋小东 王寅 胡敏 赵霞[3] WU Xiong;YANG Jing;WEI Qiyi;XU Sai;SONG Xiaodong;WANG Yin;HU Min;ZHAO Xia(Hubei Huaqiang High-tech Co.,Ltd.,Yichang 443000,China;Hubei Institute for Drug Control,Wuhan 430075,China;National Institutes for Food and Drug Control,Beijing 100050,China)

机构地区：[1]湖北华强科技股份有限公司,宜昌443000 [2]湖北省药品监督检验研究院,武汉430075 [3]中国食品药品检定研究院,北京100050

出　　处：《医药导报》2024年第5期717-721,共5页Herald of Medicine

摘　　要：目的 分析不同交联密度对五层共挤输液用膜性能的影响。方法 采用不同辐照条件,制得不同交联密度的五层共挤输液用膜样品,通过考察拉伸性能、热合性能、透光率、pH值等指标,分析不同交联密度对五层共挤输液用膜物理性能、化学性能、使用性能等方面的影响。结果 随着交联密度的增加,五层共挤输液用膜的力学性能、光学性能和热合性能均有一定程度的提升,当凝胶含量达到60%以上时,五层共挤输液用膜性能更为优异。结论 确定合适的辐照工艺对五层共挤输液用膜性能十分重要。Objective To analyze the influence of different crosslinking densities on the performance of 5-layer co-extrusion film for infusion.Methods The 5-layer co-extrusion film for infusion samples with different crosslinking densities were prepared using different irradiation conditions.By examining the tensile performance,thermal sealing performance,transmittance,pH value and other indicators,the effects of different crosslinking densities on the physical,chemical,and usage properties of the 5-layer co-extrusion film for infusion were analyzed.Results The results show that the mechanical properties,optical properties and heat sealing properties of the 5-layer co-extrusion film for infusion membrane are improved to a certain extent with the increase of the crosslinking density.When the gel content reaches more than 60%,the performance of the 5-layer co-extrusion film for infusion membrane is more excellent.Conclusion It is important to choose the appropriate irradiation process for the properties of 5-layer co-extrusion film for infusion membrane.

关 键 词：五层共挤输液用膜 交联密度 凝胶含量 湿热灭菌 

分 类 号：R943[医药卫生—药剂学] TQ460.4[医药卫生—药学]