Effects of loneliness and isolation on cardiovascular diseases:a two sample Mendelian Randomization Study  

作　　者：Jia-Yin CAI Xin WANG Cong-Yi ZHENG Xue CAO Zhen HU Run-Qing GU Yi-Xin TIAN Ye TIAN Lan SHAO Lin-Feng ZHANG Zeng-Wu WANG 

机构地区：[1]Division of Prevention and Community Health,National Center for Cardiovascular Disease,National Clinical Research Center of Cardiovascular Disease,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,Peking Union Medical College&Chinese Academy of Medical Sciences,Beijing,China

出　　处：《Journal of Geriatric Cardiology》2024年第3期340-348,共9页老年心脏病学杂志（英文版）

摘　　要：BACKGROUND Loneliness and isolation are associated with multiple cardiovascular diseases(CVDs),but there is a lack of research on whether they were causally linked.We conducted a Mendelian Randomization(MR)study to explore causal relationships between loneliness and isolation and multiple CVDs.METHODS Single nucleotide polymorphisms associated with loneliness and isolation were identified from a genome-wide association study(GWAS)of 455,364 individuals of European ancestry in the IEU GWAS database.Summary data for 15 CVDs were also obtained from the IEU GWAS database.We used three MR methods including inverse variance weighting,MR-Egger,and weighted median estimation to assess the causal effect of exposure on outcomes.Cochran's Q test and MR-Egger intercept test were used to evaluate the heterogeneity and pleiotropy.RESULTS MR analysis showed that loneliness and isolation were significantly associated with essential hypertension(OR=1.07,95%CI:1.03-1.12),atherosclerotic heart disease(OR=1.04;95%CI:1.02-1.06),myocardial infarction(OR=1.02;95%CI:1-1.04)and angina(OR=1.04;95%CI=1.02-1.06).No heterogeneity and pleiotropy effects were found in this study.CONCLUSIONS Causal relationship of loneliness and isolation with CVDs were found in this study.

关 键 词：DISEASES CARDIOVASCULAR ANGINA 

分 类 号：R54[医药卫生—心血管疾病]