阿尔茨海默病血液标志物免疫检测方法的应用研究进展  

Application progress of immunoassays for blood biomarkers of Alzheimer's disease

作　　者：蔡齐勇 康煕雄 李朝辉 Qiyong CAI;Xixiong KANG;Zhaohui LI(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;iKang Healthcare Group,Beijing 100022,China;the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]河南中医药大学药学院,郑州450046 [2]首都医科大学附属北京天坛医院,北京100070 [3]爱康集团,北京100022 [4]郑州大学第一附属医院,郑州450052

出　　处：《阿尔茨海默病及相关病杂志》2024年第2期122-128,共7页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：国家重点研发计划(2022YFC2009600,2022YFC2009603);河南省科技攻关项目(222102310501)。

摘　　要：随着阿尔茨海默病(Alzheimer's Disease,AD)研究的深入,血液标志物作为一种非侵入性检测手段在AD诊断和病程监测中的应用受到广泛关注。本文综述了AD血液标志物免疫检测方法的应用研究进展,就单分子阵列、电化学发光、免疫磁减量、化学发光、免疫沉淀-质谱联用等技术在AD血液标志物检测中的原理、优势、局限性进行综合分析,并讨论这些技术在提高检测灵敏度、特异性以及临床应用标准化方面的应用进展。With further research on Alzheimer's Disease(AD),the application of blood markers as a non-invasive test in the diagnosis and monitoring of the disease course of AD has received extensive attention.This review focuses on the progress of the application of immunoassay methods for blood markers in AD,which provides a comprehensive analysis of the principles,advantages,and limitations of single molecule array,electrochemiluminescence,immunomagnetic reduction,chemiluminescence and immunoprecipitation-mass spectrometry technologies in the detection of blood biomarkers for AD.Additionally,it explores how these technologies improve the sensitivity and specificity of detection and standardization of clinical applications.

关 键 词：阿尔茨海默病 血液生物标志物 免疫检测 

分 类 号：R741[医药卫生—神经病学与精神病学]