血清胃蛋白酶原Ⅰ、胃蛋白酶原Ⅱ、胃泌素17水平在胃癌中的表达及其联合检测对胃癌术后复发的预测价值  

Expression of serum pepsinogenⅠ,PepsinogenⅡand gastrin 17 in gastric cancer and the predictive value of combined detection for postoperative recurrence of gastric cancer

作　　者：杜世杰[1] DU Shi-jie(Department of Clinical Laboratory,Luoyang Central Hospital,Luoyang,Henan 471000,China)

机构地区：[1]洛阳市中心医院检验科,河南洛阳471000

出　　处：《医药论坛杂志》2024年第5期557-560,F0003,共5页Journal of Medical Forum

摘　　要：目的 探讨血清胃蛋白酶原Ⅰ(PGI)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素17(G-17)水平在胃癌中的表达及其联合检测对胃癌术后复发的预测价值。方法 选取2017年1月至2022年12月于洛阳市中心医院行根治性手术治疗的116例(均完成1年随访)胃癌患者为观察组,同期116例健康体检者为对照组,另根据术后1年复发情况分为复发(35例)和未复发(81例)两个亚组。比较两组术前血清PGI、PGⅡ、G-17水平,比较不同病理学参数胃癌术前血清PGI、PGⅡ、G-17水平,分析术前血清PGI、PGⅡ、G-17水平与病理学参数相关性,比较复发和未复发胃癌患者血清PGI、PGⅡ、G-17水平,分析血清PGI、PGⅡ、G-17水平联合检测对胃癌术后复发的预测价值。结果 (1)与对照组相比,术前观察组血清PGI水平较低,PGⅡ、G-17水平较高(P<0.05)。(2)术前血清PGI水平比较:T1~T2>T3~T4,Ⅰ~Ⅱ期>Ⅲ~Ⅳ期,无淋巴结转移>有淋巴结转移;术前血清PGⅡ、G-17水平比较:T1~T2<T3~T4,Ⅰ~Ⅱ期<Ⅲ~Ⅳ期,无淋巴结转移<有淋巴结转移(P<0.05)。(3)术前血清PGI水平与浸润深度、临床分期、淋巴结转移均呈负相关,血清PGⅡ、G-17水平与浸润深度、临床分期、淋巴结转移均呈正相关(P<0.05)。(4)与未复发患者相比,术后1周、术后4周复发患者血清PGI水平较低,PGⅡ、G-17水平较高(P<0.05)。(5)术后1、4周,血清PGI、PGⅡ、G-17联合预测术后复发的AUC均大于各单一指标检测(P<0.05)。结论 血清PGI、PGⅡ、G-17与胃癌进展及术后复发显著相关,可作为根治术后复发的预警指标,检测三者表达有望为术后复发的预测提供一种新的策略。Objective To investigate the expression of serum pepsinogenⅠ(PGI),pepsinogenⅡ(PGII)and gastrin 17(G-17)in gastric cancer and the predictive value of combined detection for postoperative recurrence of gastric canc⁃er.Methods A total of 116 patients with gastric cancer who received radical surgery in our hospital from January 2019 to March 2022(all completed 1-year follow-up)were selected as the observation group,and 116 healthy subjects in the same period were selected as the control group.According to the recurrence situation one year after surgery,they were divided into two subgroups:recurrence(35 cases)and non-recurrence(81 cases).The preoperative serum lev⁃els of PGI,PGII and G-17 were compared between the two groups,the serum levels of PGI,PGII and G-17 were compared before the operation of gastric cancer with different pathological parameters,the correlation between the preop⁃erative serum levels of PGI,PGII and G-17 and the pathological parameters were analyzed,and the serum levels of PGI,PGII and G-17 were compared between patients with recurrent and non-recurrent gastric cancer.To analyze the combined detection value of serum PGI,PGII and G-17 for postoperative recurrence of gastric cancer.Results①Compared with the control group,the serum PGI level in the observation group was lower before surgery,while the levels of PGII and G-17 were higher(P<0.05).②Comparison of serum PGI levels before surgery:T1~T2>T3~T4,stagesⅠ~Ⅱ>Ⅲ~Ⅳ,no lymph node metastasis>with lymph node metastasis;Comparison of ser⁃um PGII and G-17 levels before surgery:T1~T2<T3~T4,Ⅰ~Ⅱ<Ⅲ~Ⅳ,no lymph node metastasis<with lymph node metastasis(P<0.05).③Preoperative serum PGI level was negatively correlated with the depth of inva⁃sion,clinical stage and lymph node metastasis,while serum PGII and G-17 level were positively correlated with the depth of invasion,clinical stage and lymph node metastasis(P<0.05).④Compared with the patients without recur⁃rence,the serum PGI level of patients with recurrence 1 week an

关 键 词：胃癌 术后复发 血清胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 胃泌素17 

分 类 号：R735.2[医药卫生—肿瘤]