小肝综合征的发病机制及防治研究进展  

Research progress in the pathogenesis,prevention and control measures of small-for-size syndrome

作　　者：梁海锋 梁国志 袁观斗 郭振亚 何松青[1,2,3] Liang Haifeng;Liang Guozhi;Yuan Guandou;Guo Zhenya;He Songqing(Division of Hepatobiliary Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,Nanning 530021,China;Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院肝胆外科,南宁530021 [2]区域性高发肿瘤早期防治研究教育部重点实验室(广西医科大学),南宁530021 [3]广西肝脏疾病免疫与代谢研究重点实验室,南宁530021

出　　处：《中华实验外科杂志》2024年第3期639-643,共5页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(82360320);广西科技基地和人才专项(桂科AA21220002);广西医科大学高水平创新团队及杏湖学者计划;111计划(D17011)。

摘　　要：小肝综合征(SFSS)是由于术后小体积肝组织不能维持正常的功能,出现高胆红素血症伴胆汁淤积等症状的临床综合征。常见于小体积肝移植或扩大肝切除术术后。后期可出现败血症、肾功能不全、胃肠功能障碍以及出血等严重并发症。充分认识其发病机制对防治SFSS有重要积极意义。本文针对SFSS的发病机制及防治研究进展展开综述。Small-for-size syndrome(SFSS)is a clinical syndrome with symptoms such as hyperbilirubinemia with cholestasis due to the inability of small volume liver tissue to maintain normal function after surgery.It could occur after small volume liver transplantation or extended liver resection.Serious complications such as sepsis,renal insufficiency,gastrointestinal dysfunction,and bleeding may occur in the late stage.It’s significant to fully understand its mechanism for the prevention and treatment of SFSS.This review focuses on the research progress in the pathogenesis,prevention and control measures of SFSS.

关 键 词：小肝综合征 肝切除 肝移植 

分 类 号：R575[医药卫生—消化系统]