高压氧治疗对创伤性蛛网膜下腔出血患儿神经功能、脑微循环及血清miR-143水平的影响  

Effects of Hyperbaric oxygen on neurological function,cerebral microcirculation,and serum miR-143 level in children with traumatic subarachnoid hemorrhage

作　　者：王琪[1] 邵启国[1] 张丽娜[1] 何卫东 Wang Qi;Shao Qiguo;Zhang Lina;He Weidong(Pediatric Intensive Care Unit,Shangqiu First People’s Hospital,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院儿科重症监护室,商丘476100

出　　处：《中华航海医学与高气压医学杂志》2024年第1期41-45,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：河南省科技攻关项目(2HGJ20200672)。

摘　　要：目的探讨高压氧治疗对创伤性蛛网膜下腔出血患儿神经功能、脑微循环和血清miR-143水平的影响。方法前瞻性选取2015年2月至2020年5月商丘市第一人民医院儿科重症监护室收治的50例创伤性蛛网膜下腔出血患儿作为研究对象,根据治疗方法分为对照组(n=24)和观察组(n=26)。对照组患儿采用常规药物治疗,观察组患儿在对照组治疗基础上的采用高压氧治疗。比较治疗前后2组患儿的格拉斯哥昏迷量表(GCS)评分、脑微循环指标、颅内压、血清miR-143水平及预后情况。结果观察组患儿治疗1、2个疗程后的颅内压明显低于对照组,GCS评分、血清miR-143水平高于对照组,差异均有统计学意义(P<0.001);观察组患儿治疗2个疗程后的平均通过时间(MTT)、脑血流量(CBF)、脑血容量(CBV)、平均动脉压(MAP)较对照组明显改善,差异均有统计学意义(P<0.001);观察组患儿预后良好率明显高于对照组,差异有统计学意义(P<0.05)。结论高压氧治疗创伤性蛛网膜下腔出血患儿,可提高患儿的血清miR-143水平,降低颅内压,改善脑微循环及预后。Objective To explore the effect of hyperbaric oxygen on neurological function,cerebral microcirculation,and serum miR-143 level in children with traumatic subarachnoid hemorrhage.Methods A total of 50 children with traumatic subarachnoid hemorrhage admitted to the pediatric intensive care unit of Shangqiu First People’s Hospital from February 2015 to May 2020 were prospectively selected as the research objects and divided them into control group(n=24)and observation group(n=26),according to the random number table method.The children in the control group received conventional medical treatment,and the children in the observation group were treated with hyperbaric oxygen on the basis of the treatment in the control group.The Glasgow Coma Scale(GCS)score,cerebral microcirculation index,intracranial pressure,serum miR-143 level,and prognosis were compared between the two groups before and after treatment.Results After one course of treatment and two courses of treatment,the intracranial pressure of children in the observation group were all lower than that in the control group,and the GCS score and serum miR-143 level were all higher than those in the control group,with statistically significant differences(P<0.05);the mean transit time(MTT),cerebral blood flow(CBF),cerebral blood volume(CBV),and mean arterial pressure(MAP)of the children in the observation group after two courses of treatment were all significantly improved compared with those in the control group,with statistically significant differences(P<0.05);the good prognosis rate of the observation group was higher than that of the control group,with statistically significant differences(P<0.05).Conclusion Hyperbaric oxygen for children with traumatic subarachnoid hemorrhage can elevate the level of serum miR-143,reduce intracranial pressure,and improve cerebral microcirculation and prognosis.

关 键 词：创伤性蛛网膜下腔出血 高压氧 脑微循环 miR?143 颅内压 

分 类 号：R743.35[医药卫生—神经病学与精神病学]