S-亚硝基谷胱甘肽在创伤修复中的应用进展  

Advances in application of S-nitrosoglutathione in trauma repairing

作　　者：石嫒 贾含香 容德昌 刘玲童 黄胜 朱红敏[4] 伍莉[5] 王军[1,2,3] SHI Ai;JIA Hanxiang;RONG Dechang;LIU Lingtong;HUANG Sheng;ZHU Hongmin;WU Li;WANG Jun(Provincial Ministry of Industrial Fermentation Co-operative Innovation Centre,Hubei University of Technology,Wuhan 430068,China;National“111”Center for Cellular Regulation and Molecular Pharmaceutics,Hubei University of Technology,Wuhan 430068,China;Institute for Autism Depression and Intervention,Hubei University of Technology,Wuhan 430068,China;Wuhan Children′s Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430016,China;South-Central Minzu University,Wuhan 430074,China)

机构地区：[1]湖北工业大学工业发酵省部共建协同创新中心,湖北武汉430068 [2]湖北工业大学孤独症抑郁症与干预研究所,湖北武汉430068 [3]湖北工业大学细胞调控与分子药物学科创新引智基地,湖北武汉430068 [4]华中科技大学同济医学院附属武汉儿童医院,湖北武汉430016 [5]中南民族大学,湖北武汉430074

出　　处：《生物技术》2024年第1期114-119,共6页Biotechnology

基　　金：国家自然科学基金项目(82061138005);湖北省教育厅创新团队项目(T2020009)。

摘　　要：创伤修复的治疗对缩短恢复时间、减少患者痛苦和预防并发症至关重要。S-亚硝基谷胱甘肽(S-nitrosoglutathione,GSNO)作为一氧化氮的天然供体,具有抗菌、抗炎和促进细胞增殖的作用,已逐渐成为创伤修复再生领域的研究热点。因此,了解GSNO在创伤修复中的作用机制可为将来开发治疗创伤的新疗法提供有力的依据。该文总结了GSNO在促进创伤修复中的研究进展,重点描述其抗菌活性、抗炎症反应和促进细胞增殖等方面的作用机制,还阐述了GSNO治疗创伤修复研究中的应用,以期为后续的深入研究提供思路。The treatment of trauma repairing is essential to shorten recovery time,reduce patient suffering and prevent complications.S-nitrosoglutathione(GSNO),a natural donor of nitric oxide,has become a hot topic of research in the field of trauma repairing and regeneration because of its antibacterial,anti-inflammatory and cell proliferation-promoting effects.Therefore,understanding the mechanism of GSNO in trauma repairing can provide a strong basis for the development of new therapies for the treatment of trauma in the future.This paper summarizes the research progress of GSNO in promoting trauma repairing,focusing on the mechanism of its antibacterial activity,anti-inflammatory response and promotion of cell proliferation,and also describes the application of GSNO in the study of trauma repairing,in order to provide ideas for further research.

关 键 词：创伤修复 S-亚硝基谷胱甘肽 一氧化氮 抗菌 水凝胶 微纳米材料 抗炎 细胞增殖 

分 类 号：R914.4[医药卫生—药物化学]