线粒体在肺癌发生中的作用机制及治疗研究进展  

Research Progress in Mitochondrial Treatment and Mechanism in Occurrence of Lung Cancer

作　　者：吴发胜[1] 张晖 谢家童 李建福 陈慧 鲁世金[1] WU Fasheng;ZHANG Hui;XIE Jiatong;LI Jianfu;CHEN Hui;LU Shijin(Department of Radiotherapy,Ruikang Hospital,Guangxi University of Chinese Medicine,Nanning 530011,China;Ruikang Clinical Medical College,Guangxi University of Chinese Medicine,Nanning 530001,China)

机构地区：[1]广西中医药大学附属瑞康医院放疗科,南宁530011 [2]广西中医药大学瑞康临床医学院,南宁530001

出　　处：《肿瘤防治研究》2024年第4期278-283,共6页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(82260944);博士科研项目(2018BS056)。

摘　　要：肺癌具有高发生率、高侵袭性和高致亡率的特点,其发生发展受多方面因素影响。线粒体作为普遍存在于人体内的细胞器,通过调节细胞代谢、信号转导、氧化应激和基因组不稳定性等过程,影响肺癌的发生和发展。本文总结近年来有关线粒体靶向药物、线粒体转移和线粒体基因疗法等治疗肺癌的研究进展,探讨线粒体治疗肺癌的原理和前景,以期为肺癌的治疗提供新的思路。Lung cancer is characterized by high incidence and mortality rates and invasiveness,and its occurrence and development are influenced by various factors.Mitochondria,as ubiquitous organelles in the human body,regulate cellular processes,such as metabolism,signal transduction,oxidative stress,and genomic instability,thereby affecting the initiation and progression of lung cancer.This article summarizes the recent research progress on mitochondrial-targeted drugs,mitochondrial transfer,and mitochondrial gene therapy for lung cancer treatment.This work also discusses the principles and prospects of mitochondrial therapy to provide new insights for lung cancer treatment.

关 键 词：线粒体 肺癌 作用机制 治疗 

分 类 号：R734.2[医药卫生—肿瘤]