肿瘤相关巨噬细胞来源的外泌体在消化系统肿瘤中的作用机制及治疗进展  

Mechanism and treatment progress of exosomes derived from tumor-associated macrophages in digestive system tumors

作　　者：刘小央 闵晓翠 王芙蓉[3] Liu Xiaoyang;Min Xiaocui;Wang Furong(Department of General Surgery,Gansu Provincial Hospital,Lanzhou 730000,China;Department of Hepatology,The Second Hospital of Lanzhou University,Lanzhou 730030,China;Department of Pathology,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]甘肃省人民医院普通外科,甘肃兰州730000 [2]兰州大学第二医院肝病科,甘肃兰州730030 [3]兰州大学第二医院病理科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2024年第2期87-94,共8页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省自然科学基金资助项目(22JR11RA054)。

摘　　要：肿瘤相关巨噬细胞是肿瘤微环境中的重要细胞群,分泌多种细胞因子促进肿瘤进展。肿瘤相关巨噬细胞通过向肿瘤细胞递送包含蛋白质、脂质和多种类型核糖核酸的外泌体促进肿瘤增殖、侵袭、转移、血管生成,并增强肿瘤细胞的耐药性。本研究综述肿瘤相关巨噬细胞分泌的外泌体对消化系统肿瘤的调节作用及其分子机制,并从外泌体角度介绍防治消化系统肿瘤的策略,为临床药物的开发提供新思路。Tumor-associated macrophages play a crucial role in the tumor microenvironment by releasing different cytokines to facilitate tumor progression.In addation,these macrophages promote tumor proliferation,invasion,metastasis,angiogenesis,and enhance drug resistance by transmitting exosomes containing proteins,lipids and various types of ribonucleic acid to tumor cells.This review examined the regulatory effects and molecular mechanisms of tumor-associated macrophage-derived exosomes on digestive system tumors.Additionally,it presents strategies to prevent and treat digestive system tumors based on exosome research,offering new insights into the development of clinical drugs.

关 键 词：肿瘤相关巨噬细胞 肿瘤微环境 外泌体 消化系统肿瘤 免疫治疗 

分 类 号：R735.2[医药卫生—肿瘤]