云南省一起热带紫褐裸伞中毒事件调查及毒素鉴定  

Investigation and toxin identification of a poisoning incident caused by Gymnopilus dilepis in Yunnan Province

作　　者：陈汝梅 黄小芹 阮燕明 孙明月 陈敏[1] 林佶[1] CHEN Rumei;HUANG Xiaoqin;RUAN Yanming;SUN Mingyue;CHEN Min;LIN Ji(Yunnan Provincial Key Laboratory of Public Health and Biosafety&Health Labratory Center,Yunnan Center for Disease Control and Prevention,Yunnan Kunming 650032,China)

机构地区：[1]云南省公共卫生与食物安全重点实验室云南省疾病预防控制中心,云南昆明650032

出　　处：《中国食品卫生杂志》2024年第1期84-87,共4页Chinese Journal of Food Hygiene

摘　　要：目的对一起热带紫褐裸伞中毒事件进行快速毒素筛查和对患者临床症状及治疗进行讨论,以期为此类事件的处置及临床救治提供参考。方法利用超高效液相色谱-三重四级杆串联质谱对中毒事件剩余的毒蘑菇进行检测,根据流行病学调查方法,收集病例资料,并结合调查结果和患者的肝肾功能指标进行分析。结果从中毒患者食用的热带紫褐裸伞中检测出裸盖菇素及毒蝇碱,患者症状与裸盖菇素和毒蝇碱中毒症状相似,表现为幻觉、恶心、呕吐、腹痛、腹泻等,肝肾功能指标正常。结论此次中毒事件是由热带紫褐裸伞中的裸盖菇素及毒蝇碱引起。Objective To provide reference for the disposition and clinical treatment of poisoning incidents,rapid toxin screening and the clinical symptoms and treatment of a case of Gymnopilus dilepis poisoning were conducted and discussed.Methods Ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry was used to detect the remaining poisonous mushroom in the contaminated food.Based on an epidemiological investigation,case data were collected.The results of the epidemiological investigation and the liver and kidney indexes of the patients were analyzed.Results Psilocybin and muscarine were detected in the Gymnopilus dilepis consumed by the patients.The symptoms were similar to those of psilocybin and muscarine poisoning,which included hallucinations,nausea,vomiting,abdominal pain,and diarrhea.The liver and kidney functions were normal.Conclusion The poisoning event was caused by psilocybin and muscarine in Gymnopilus dilepis.

关 键 词：热带紫褐裸伞 裸盖菇素 毒蝇碱 超高效液相色谱串联质谱 毒蘑菇 云南 

分 类 号：R155[医药卫生—营养与食品卫生学]