金黄色葡萄球菌异质性耐药研究进展  

Research Progress in Heteroresistance of Staphylococcus aureus

作　　者：和晓兰 赵艳坤 孟璐[1] 刘慧敏[1] 高姣姣 郑楠[1] HE Xiaolan;ZHAO Yankun;MENG Lu;LIU Huimin;GAO Jiaojiao;ZHENG Nan(Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China;Ministry of Agriculture and Rural Affairs-Laboratory of Quality and Safety Risk Assessment for Agro-Products(Urumgi),Key Laboratory of Agro-Products Quality and Safety of Xinjiang,Institute of Quality Standards&Testing Technology for Agro-Products,Xinjiang Academy of Agricultural Sciences,Urumqi 830091,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193 [2]新疆农业科学院农业质量标准与检测技术研究所农业农村部农产品质量安全风险评估实验室(乌鲁木齐)新疆农产品质量安全实验室,乌鲁木齐830091

出　　处：《畜牧兽医学报》2024年第4期1432-1445,共14页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家重点研发计划(2022YFD1301003);国家现代农业产业技术体系(CARS36);农产品质量安全风险评估(GJFP20220304);中国农业科学院科技创新工程(ASTIP-IAS12);国家农产品质量安全风险评估项目(14225001);国家自然科学基金(32060797);天山创新团队(2022D14016)。

摘　　要：金黄色葡萄球菌(Staphylococcus aureus,S.aureus)是人类和动物感染的常见病原菌。近年来,金黄色葡萄球菌已经对多种抗菌药物出现耐药性,关于金黄色葡萄球菌异质性耐药的研究也被频繁报道。异质性耐药现象是指存在异质性细菌种群,其中一个亚群或几个亚群与主要种群相比表现出更高水平的抗菌药物耐药性。该定义反映出异质性耐药现象具有很多特点,包括克隆性、稳定性、不同亚群的耐药水平以及异质性耐药亚群的频率应在10^(-7)及以上。异质性耐药可看成是敏感表型向耐药表型转化的中间阶段,往往导致临床治疗的失败。本文对异质性耐药的定义、检测方法等进行了介绍,并综述了金黄色葡萄球菌对糖肽类、磺胺类、β-内酰胺类和其他抗菌药物异质性耐药的流行情况及异质性耐药机制的研究,旨在加强对金黄色葡萄球菌异质性耐药的认识,以期为学者了解金黄色葡萄球菌异质性耐药流行情况及机制提供参考。Staphylococcus aureus(S.aureus)is a common cause of infection in humans and animals.In recent years,S.aureus has become resistant to a variety of antimicrobial drugs,and studies on heteroresistance in S.aureus have been frequently reported.The broadest definition of heteroresistance is the presence of a heterogeneous population of bacteria with one subpopulation or several subpopulations that exhibit increased levels of antibiotic resistance compared with the main population.However,this definition includes phenomena with very different characteristics;for example,clonality of resistant subpopulations,the stability of the resistant subpopulations,the resistance level of the resistant subpopulations,and at a frequency greater than 1×10^(-7).Heteroresistance is the intermediate stage of sensitive bacteria evolving into drug-resistant bacteria,which often leads to the failure of clinical therapy.This paper introduces the definition of heteroresistance,detection methods,etc.,and reviews the prevalence of heteroresistance of S.aureus to glycopeptides,sulfonamides,β-lactams,and other antibacterial agents and the study of the mechanism of heteroresistance.It is aimed to strengthen the understanding on the heteroresistance of S.aureus,and to provide a reference for scholars to understand the prevalence and mechanism of heteroresistance of S.aureus.

关 键 词：金黄色葡萄球菌 异质性耐药 抗菌药物 流行情况 机制 

分 类 号：S852.611[农业科学—基础兽医学]