高压氧治疗老年认知衰弱临床疗效观察  

Clinical efficacy of hyperbaric oxygen on the elderly patients with cognitive frailty

作　　者：洪珊珊 王庆广 韩伯军 陈灵芝 王云 陈丹凤 HONG Shanshan;WANG Qingguang;HAN Bojun;CHEN Lingzhi;WANG Yun;CHEN Danfeng(Department of Neurology,Jiangyin Hospital Affiliated to Nantong University(Jiangyin People's Hospital),Jiangyin 214400,China;Department of Hyperbaric Oxygen,Jiangyin Hospital Affiliated to Nantong University(Jiangyin People's Hospital),Jiangyin 214400,China)

机构地区：[1]南通大学附属江阴医院、江阴市人民医院神经内科,江苏江阴214400 [2]南通大学附属江阴医院、江阴市人民医院高压氧科,江苏江阴214400

出　　处：《老年医学研究》2024年第2期14-16,共3页Geriatrics Research

基　　金：无锡市卫健委面上项目(M202116,血管紧张素Ⅳ在帕金森病及相关认知功能障碍中的治疗作用及潜在机制研究)。

摘　　要：目的探讨高压氧治疗老年认知衰弱的临床疗效。方法选取2020年6月—2023年6月在南通大学附属江阴医院就诊的老年认知衰弱患者56例为研究对象,根据治疗方式分为高压氧组和对照组。两组均给予常规康复治疗,高压氧组在此基础上联合高压氧治疗。治疗前后分别采用Tilburg衰弱评估量表(TFI量表)和蒙特利尔认知评估量表(MoCA量表)评估患者的衰弱状况和认知功能。结果治疗后,高压氧组TFI总分及各因子得分低于对照组,高压氧组MoCA总分、视空间与执行能力、命名、定向力因子得分高于对照组(P均<0.05)。高压氧组治疗后TFI总分、生理维度、心理维度得分低于治疗前,治疗后MoCA总分、视空间与执行能力、命名、注意、抽象概括、延迟回忆、定向力因子得分均较治疗前增加(P均<0.05)。结论高压氧治疗老年认知衰弱疗效显著,可改善患者的衰弱状况和认知功能。Objective To investigate the clinical effects of hyperbaric oxygen(HBO)on the elderly patients with cognitive frailty.Methods Fifty-six elderly patients with cognitive frailty who were treated at Jiangyin Hospital affiliated to Nantong University from June 2020 to June 2023 were selected as the research subjects,and were divided into hyperbaric oxygen group and control group according to the treatment method.Both groups were given routine rehabilitation treatment,while the hyperbaric oxygen group was combined with HBO treatment on this basis.Before and after treatment,the patients'debility and cognitive function were assessed with the Tilburg frailty indicator(TFI scale)and the Montreal cognitive assessment(MoCA scale).Results After treatment,the total TFI score and various factor scores of the hyperbaric oxygen group were lower than those of the control group(all P<0.05).The total MoCA score,visual space and executive function,naming and orientation factor scores of the hyperbaric oxygen group were higher than those of the control group(all P<0.05).After treatment,the total score of TFI,physiological dimension and psychological dimension in the hyperbaric oxygen group were lower than those before treatment(all P<0.05).After treatment,the total score of MoCA,visual space and executive function,naming,attention,abstraction,delayed memory,and orientation factor scores all increased compared to those before treatment(all P<0.05).Conclusion HBO has significant therapeutic effects on cognitive frailty in elderly patients,which can improve their frailty status and cognitive function.

关 键 词：高压氧 认知衰弱 老年人 Tilburg衰弱量表 蒙特利尔认知量表 康复 

分 类 号：R74[医药卫生—神经病学与精神病学]