全身免疫炎症指数与幕上脑出血急性期预后相关性的研究  

Relationship between systemic immune-inflammation index and acute prognosis of supratentorial intracerebral hemorrhage

作　　者：陈冉冉 张亚丽 赵淑敏[1] 张晶晶 安翼 白雪[1,2] CHEN Ranran;ZHANG Yali;ZHAO Shumin(Chifeng Clinical Medical College of Inner Mongolia Medical University,Chifeng 024000,China)

机构地区：[1]内蒙古医科大学赤峰临床医学院,内蒙古赤峰024000 [2]赤峰市医院神经内科,内蒙古赤峰024000

出　　处：《中风与神经疾病杂志》2024年第4期361-364,共4页Journal of Apoplexy and Nervous Diseases

基　　金：内蒙古自治区自然科学基金(2022SHZR1527);内蒙古自治区自然科学基金(2020MS08082)。

摘　　要：目的 论证全身免疫炎症指数(SII)与脑出血(ICH)急性期预后的关系。方法 回顾性收集2021年1月―2022年1月内蒙古医科大学赤峰临床医学院神经内科收治的幕上ICH患者的临床病例资料,依据患者预后情况(mRS 3~6分定义为预后不良)及SII指数四分位间距进行分组,比较不同预后患者间基线资料和SII指数差异,并进一步分析SII指数升高与NIHSS评分、出血量的关系。结果 与预后良好组相比,预后不良组具有更大的SII指数,更大的出血量,更高的破入脑室比例,以及更高的白细胞计数和中性粒细胞计数(P<0.001)。依据SII指数四分位数进行分组后发现:SII指数≥1.58患者较SII指数≤0.53患者具有更高的NIHSS评分;更大的出血量,差异均具有显著统计学意义(P<0.001)。结论 SII指数与幕上ICH患者急性期预后相关,调控神经炎症反应可能有利于ICH患者预后。Objective To study the relationship between the systemic immune-inflammation(SII)index and the prognosis of intracerebral hemorrhage(ICH)in the acute phase.Methods We retrospectively collected the clinical data of patients with supratentorial ICH admitted to the Department of Neurology of Chifeng Clinical Medical College of Inner Mongolia Medical University from January 2021 to January 2022.The patients were grouped according to their outcomes(a modified Rankin Scale score of 3-6 points was considered as a poor prognosis)and SII index quartiles.The baseline data and SII index of patients with different prognoses were compared.The relationship between the SII index and the National Institutes of Health Stroke Scale(NIHSS)score and hemorrhage volume was analyzed.Results Compared with patients with a good prognosis,those with a poor prognosis had a significantly greater SII index,a significantly larger hemorrhage volume,a significantly higher proportion of intraventricular extension,and significantly higher leukocyte and neutrophil counts(all P<0.001).Patients with the SII index≥1.58 had a significantly higher NIHSS score and a significantly larger hemorrhage volume than patients with the SII index≤0.53(both P<0.001).Conclusion The SII index is related to the acute prognosis of patients with supratentorial ICH,suggesting that regulating neuroinflammatory response may improve the prognosis of patients with ICH.

关 键 词：脑出血 全身免疫炎症指数 改良Rankin量表 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]