不同组织来源的外泌体在非酒精性脂肪性肝病发展中的作用  

The Role of Exosome from Different Tissues in the Development of NAFLD

作　　者：曹杰 袁莉[1] Cao Jie;Yuan Li(Department of Endocrinology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,武汉430022

出　　处：《华中科技大学学报（医学版）》2024年第2期256-261,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.82170812,No.81974104)。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种受多种肝外器官影响的慢性肝脏疾病,尚无有效治疗药物,严重威胁人类健康。其发病机制复杂,目前尚未完全阐明。近年来的研究提示外泌体在肝脏糖脂代谢、炎症反应和慢性纤维化发展过程中发挥着至关重要的作用,逐渐被认为是NAFLD发生发展中的新型关键信号调节因素。作为一种多细胞来源的信号载体,不同细胞或组织来源的外泌体在NAFLD的病理发展过程中起到不同的作用。该文探讨了不同细胞或组织来源的外泌体在NAFLD发病中的作用,为未来临床防治NAFLD开辟新方向提供理论基础。Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease affected by a variety of extra-hepatic organs.Until now, there is no effective treatment for NAFLD,which seriously threatens health of all mankind.The pathogenesis of NAFLD is very complex and has not been fully elucidated.Recent studies have revealed that exosomes play a crucial role in glucose and lipid metabolism, inflammatory response and development of chronic fibrosis of liver.Exosomes are gradually considered as novel key signal regulator in the occurrence and development of NAFLD.As a signal carrier of multicellular origin, exosomes from different cells or tissues play different roles in the pathological development of NAFLD.In this study, the role of exosomes from different cells or tissues in the pathogenesis of NAFLD was discussed, which provides a new therapeutic direction for clinical treatment of NAFLD in the future.

关 键 词：非酒精性脂肪性肝病 外泌体 炎症反应 胰岛素抵抗 发病机制 

分 类 号：R575.5[医药卫生—消化系统]