造血干细胞生成免疫细胞的潜力及其应用研究进展  

Research progress of haematopoietic stem cells to generate immune cells and its application

作　　者：张雅琳 李娟娟 闫鹏辉 周瑾 庄玉洁 张雪梅 王小龙 张君涛[1] 张志平[1] 邓立新[1] ZHANG Yalin;LI Juanjuan;YAN Penghui;ZHOU Jin;ZHUANG Yujie;ZHANG Xuemei;WANG Xiaolong;ZHANG Juntao;ZHANG Zhiping;DENG Lixin(College of Veterinary Medicine,Henan Agriculture University,Zhengzhou 450046;HenanYinfeng Bioengineering Technology Co.,Ltd,Zhengzhou 450000,China)

机构地区：[1]河南农业大学动物医学院临床兽医系,河南郑州450046 [2]河南省银丰生物工程技术有限公司,河南郑州450000

出　　处：《细胞与分子免疫学杂志》2024年第3期279-286,共8页Chinese Journal of Cellular and Molecular Immunology

基　　金：河南省自然科学基金(212300410355);国家肉牛牦牛产业技术体系(CARS-37)。

摘　　要：造血干细胞(HSC)具有高度自我更新、增殖和多向分化等潜能。长期以来,HSC移植一直是治疗血液性疾病和自身免疫性疾病的主要方法,而移植后免疫系统的重建能力是评价移植是否成功的关键。为了提高移植后免疫系统的重建能力,目前研究多集中于基因工程,以及利用规律间隔成簇短回文重复序列(CRISPR)基因编辑技术改造HSC作为移植细胞的来源。本文主要对HSC的生物学特性、调控机制、分化为免疫细胞的能力以及在治疗血液、免疫缺陷、癌症等相关疾病的应用及其研究进展进行总结,以期为相关疾病的研究提供参考。Hematopoietic stem cells(HSCs)posses the potential for highly self-renewal,proliferation and multi-lineage differentiation.HSC transplantation has long been the primary method for treating hematologic disorders and autoimmune diseases,and the ability to rebuild the immune system after transplantation is a key indicator of success.To enhance the reconstruction ability of the immune system after transplantation,current research focuses on genetic engineering and the use of HSCs modified by clustered regularly interspaced short palindromic repeats(CRISPR)gene editing technology as a source of transplant cells.This article summaries the biological characteristics,regulatory mechanism,ability to differentiate into immune cells,as well as the application and advance in the treatment of blood disorders,immune deficiencies,cancers and other related diseases,aiming to provide references for the research on relevant diseases.

关 键 词：造血干细胞 免疫细胞 基因工程 调控机制 综述 

分 类 号：R459.9[医药卫生—治疗学] R392.12[医药卫生—临床医学] G353.11[文化科学—情报学]