MGMT启动子甲基化在接受放化疗的新发 野生型胶质母细胞瘤患者中的预后作用  

Prognostic role of MGMT promoter methylation in emerging wild-type glioblastoma patients undergoing chemoradiotherapy

作　　者：古威芹 李晨曦[3,4] 陈小红 苏丽萍[2] 郑亚杰[5] GU Weiqin;LI Chenxi;CHEN Xiaohong(Second Department of Neurosurgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院神经外二科,乌鲁木齐830054 [2]新疆医科大学第一附属医院病理科,乌鲁木齐830054 [3]新疆医科大学第一附属医院(附属口腔医院)口腔颌面肿瘤外科,新疆维吾尔自治区口腔医学研究所 [4]华中科技大学同济医学院附属协和医院,口腔颌面发育与再生湖北省重点实验室 [5]汉堡-埃彭多夫大学医学中心肿瘤遗传学和再生医学实验室神经内科

出　　处：《临床神经外科杂志》2024年第2期182-186,共5页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金资助项目(82360256)。

摘　　要：目的探求O^(6)-甲基鸟嘌呤DNA甲基转移酶(MGMT)启动子甲基化对新发野生型胶质母细胞瘤(GBM)患者术后预后质量的影响。方法回顾性分析2019年1月—2022年12月在新疆医科大学第一附属医院神经外科新诊断的41例异柠檬酸脱氢酶(IDH)野生型GBM患者的临床资料,通过焦磷酸测序评估GBM患者的MGMT启动子甲基化状态,同时分析与患者预后质量的相关性。结果所有患者的MGMT启动子甲基化发生率为43%。MGMT启动子甲基化的患者中位生存期明显长于未甲基化患者(P<0.05),甲基化患者的总生存期也明显长于未甲基化患者(P<0.05)。结论MGMT启动子甲基化可延长IDH野生型GBM患者术后放化疗后生存期,但未见线性关系,提示MGMT启动子甲基化对预后的影响程度可能不同。Objective To explore the O^(6)-methylguanine DNA methyltransferase(MGMT)promoter methylation on the quality of postoperative prognosis in patients with new wild-type glioblastoma(GBM).Methods The clinical data of 41 patients with wild-type GBM isocitrate dehydrogenase(IDH)newly diagnosed in Department of Neurosurgery,the First Affiliated Hospital of Xinjiang Medical University from 2019 to 2022 were analyzed retrospectively.MGMT promoter methylation status was assessed in GBM patients by pyrosequencing,while simultaneously analyzed for correlation with patient outcome quality.Results The incidence of MGMT promoter methylation in all patients was 43%.Patients with MGMT methylated promoters had significantly higher median survival than unmethylated patients(P<0.05),and overall survival was significantly longer than unmethylated patients(P<0.05).Conclusion MGMT promoter methylation can prolong the survival after postoperative chemoradiotherapy in patients with IDH wild-type GBM,but no linear relationship is observed,which suggesting that the effect of MGMT promoter methylation on prognosis may be different.

关 键 词：胶质母细胞瘤 MGMT 甲基化 烷化治疗 焦磷酸测序 

分 类 号：R739.41[医药卫生—肿瘤]